CAS 637-01-4|TMPD dihydrochloride
| Common Name | TMPD dihydrochloride | ||
|---|---|---|---|
| CAS Number | 637-01-4 | Molecular Weight | 237.169 |
| Density | / | Boiling Point | 260.6ºC at 760 mmHg |
| Molecular Formula | C10H18Cl2N2 | Melting Point | 222-224 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 104.9ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
TMPD dihydrochloride BiologicalActivity
| Description | TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| In Vitro | TMPD (N,N,N′,N′-tetramethyl-para-phenylene-diamine) is used in cell culture and microbiology to differentiate organisms that exhibit cytochrome c oxidase activity and to distinguish between Gram-negative and Gram-positive pathogenic and non-pathogenic bacteria. The concept of TMPD oxidation by microorganisms is widely used and is known as a successful colorimetric indicator for bacterial oxidases, as the radical cation TMPD+˙, formed by oxidation, shows a characteristic deep blue colour. The electrochemical recognition of the TMPD oxidation by bacterial oxidases can be applied to a variety of pathogens[1]. |
| References | [1]. S Kuss, et al. Electrochemical recognition and quantification of cytochrome c expression in Bacillus subtilis and aerobe/anaerobe Escherichia coli using N, N, N', N'-tetramethyl- para-phenylene-diamine (TMPD). Chem Sci. 2017 Nov 1;8(11):7682-7688. [2]. Nenad Petrovic, et al. Using N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) to assay cyclooxygenase activity in vitro. Methods Mol Biol. 2010;594:129-40. [3]. Franco A Rossato, et al. Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration. PLoS One. 2014 Jun 25;9(6):e101060. |
Chemical & Physical Properties
| Boiling Point | 260.6ºC at 760 mmHg |
|---|---|
| Melting Point | 222-224 °C(lit.) |
| Molecular Formula | C10H18Cl2N2 |
| Molecular Weight | 237.169 |
| Flash Point | 104.9ºC |
| Exact Mass | 236.084702 |
| PSA | 6.48000 |
| LogP | 3.42260 |
| InChIKey | FBHKTSXMTASXFJ-UHFFFAOYSA-N |
| SMILES | CN(C)c1ccc(N(C)C)cc1.Cl.Cl |
| Storage condition | Store at RT. |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Water Solubility | SOLUBLE |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S26-S36-S36/37 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
| HS Code | 29215190 |
Customs
| HS Code | 2921519090 |
|---|---|
| Summary | 2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine,dihydrochloride |
| MFCD00012482 |
| N,N,N',N'-Tetramethylbenzol-1,4-diamindihydrochlorid |
| 1,4-Benzenediamine, N,N,N,N-tetramethyl-, hydrochloride (1:2) |
| Wurster's reagent dihydrochloride |
| N,N,N',N'-Tetramethyl-P-phenylenediaminedihydrochloride |
| 1,4-Benzenediamine, N,N,N',N'-tetramethyl-, dihydrochloride |
| N,N,N',N'-Tetramethylbenzene-1,4-diamine dihydrochloride |
| N,N,N',N'-Tetramethyl-1,4-benzenediamine dihydrochloride |
| EINECS 211-274-8 |
