Introduction：Basic information about CAS 64706-54-3|BEPRIDIL HYDROCHLORIDE MONOHYDRATE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BEPRIDIL HYDROCHLORIDE MONOHYDRATE |
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| CAS Number | 64706-54-3 | Molecular Weight | 366.54000 |
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| Density | 1.054 g/cm3 | Boiling Point | 492.3ºC at 760 mmHg |
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| Molecular Formula | C24H34N2O | Melting Point | / |
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| MSDS | / | Flash Point | 133.2ºC |
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Names
| Name | bepridil |
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| Synonym | More Synonyms |
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BEPRIDIL HYDROCHLORIDE MONOHYDRATE BiologicalActivity
| Description | Bepridil ((±)-Bepridil) is a calcium channel blocking agent used as antiarrhythmic agent. Bepridil inhibits both calcium and sodium currents, has research potential in certain ischemia-induced ventricular arrhythmias. Bepridil also has strong inhibition of SARS-CoV-2 from entry and replication inside Vero E6 and A549 cells[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>SARS-CoV |
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| Target | Calcium channel, Sodium channel, SARS-CoV-2[1][2] |
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| References | [1]. Yatani A, et al. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17. [2]. Vatansever EC, et al. Bepridil is potent against SARS-CoV-2 in vitro. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2012201118. |
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Chemical & Physical Properties
| Density | 1.054 g/cm3 |
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| Boiling Point | 492.3ºC at 760 mmHg |
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| Molecular Formula | C24H34N2O |
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| Molecular Weight | 366.54000 |
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| Flash Point | 133.2ºC |
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| Exact Mass | 366.26700 |
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| PSA | 15.71000 |
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| LogP | 4.76810 |
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| Index of Refraction | 1.572 |
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| InChIKey | UIEATEWHFDRYRU-UHFFFAOYSA-N |
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| SMILES | CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UX9710500
- CHEMICAL NAME :
- 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmeth yl)-
- CAS REGISTRY NUMBER :
- 64706-54-3
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C24-H34-N2-O
- MOLECULAR WEIGHT :
- 366.60
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 180 mg/kg/30D-I
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 90 mg/kg/3W-I
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 111,1005,1986
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Org 5730 |
| Bepridil (INN) |
| Bepadin |
| N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline |
| Vascor |
| Bepadin (TN) |
| Cordium |
| CERM 1978 |
