CAS 498-21-5|UNII:H1547KG7UZ
| Common Name | UNII:H1547KG7UZ | ||
|---|---|---|---|
| CAS Number | 498-21-5 | Molecular Weight | 132.115 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 236.5±13.0 °C at 760 mmHg |
| Molecular Formula | C5H8O4 | Melting Point | 110-115 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 111.1±16.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-Methylsuccinic acid |
|---|---|
| Synonym | More Synonyms |
UNII:H1547KG7UZ BiologicalActivity
| Description | 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy. |
|---|---|
| Related Catalog | Natural Products >>Acids and AldehydesResearch Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy[1]. The underlying biochemical defect involves isoleucine catabolism[2]. |
| References | [1]. Grosso S, et al. Ethylmalonic encephalopathy: further clinical and neuroradiological characterization. J Neurol. 2002 Oct;249(10):1446-50. [2]. Nowaczyk MJ, et al. Ethylmalonic and methylsuccinic aciduria in ethylmalonic encephalopathy arise from abnormal isoleucine metabolism. Metabolism. 1998 Jul;47(7):836-9. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 236.5±13.0 °C at 760 mmHg |
| Melting Point | 110-115 °C(lit.) |
| Molecular Formula | C5H8O4 |
| Molecular Weight | 132.115 |
| Flash Point | 111.1±16.3 °C |
| Exact Mass | 132.042252 |
| PSA | 74.60000 |
| LogP | -0.24 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.474 |
| InChIKey | WXUAQHNMJWJLTG-UHFFFAOYSA-N |
| SMILES | CC(CC(=O)O)C(=O)O |
| Stability | Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents. |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2917190090 |
Customs
| HS Code | 2917190090 |
|---|---|
| Summary | 2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles24
More Articles| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. Clin. Chem. 40(6) , 862-6, (1994) Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days... | |
| SPE-NMR metabolite sub-profiling of urine. Anal. Bioanal. Chem 404(8) , 2349-61, (2012) NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of hu... | |
| Concentrations of riboflavin and related organic acids in children with protein-energy malnutrition. Am. J. Clin. Nutr. 71(4) , 978-86, (2000) Riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD) concentrations have been little studied in cases of malnutrition.Our objective was to investigate the effects of malnutri... |
Synonyms
| UNII:H1547KG7UZ |
| d-Methylsuccinic acid |
| 2-methylbutanedioic acid |
| 2-Methylsuccinic acid |
| Pyrotartaric Acid |
| METHYLSUCCINIC ACID |
| MFCD00002659 |
| Butanedioic acid, 2-methyl- |
| EINECS 207-857-1 |
| Methylbutanedioic acid |
