Introduction：Basic information about CAS 5813-86-5|3-Methoxybenzamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3-Methoxybenzamide |
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| CAS Number | 5813-86-5 | Molecular Weight | 151.163 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 280.0±23.0 °C at 760 mmHg |
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| Molecular Formula | C8H9NO2 | Melting Point | 132.5-135.5 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 146.8±18.9 °C |
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Names
| Name | 3-methoxybenzamide |
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| Synonym | More Synonyms |
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3-Methoxybenzamide BiologicalActivity
| Description | 3-Methoxybenzamide (3-MBA), an inhibitor of ADP-ribosyltransferase (ADPRTs) and PARP, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells[1]. 3-Methoxybenzamide (3-MBA) enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum)[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Epigenetics >>PARPSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| In Vitro | 3-Methoxybenzamide (0-30 mM) affects septation via the FtsZ system during both vegetative growth and sporulation[1]. 3-Methoxybenzamide (3 MB; 0.2 to 0.6 mM) significantly increaseS the growth and microtuber formation of in vitro propagated plants[2]. Cell Viability Assay[1] Cell Line: ftsZ mutant strains. Concentration: 0-30 mM. Incubation Time: 30℃ overnight. Result: Changes directly or indirectly the ability of ftsZ to bind or hydrolyze the guanine nucleotide, ultimately leading to the inhibition of Zring formation. |
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| References | [1]. Y Ohashi, et al. The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis. J Bacteriol. 1999 Feb;181(4):1348-51. [2]. Venkateswari J. Chetty, et al. Poly (ADP-ribose) polymerase inhibitor 3-methoxybenzamide enhances in vitro plant growth, microtuberization, and transformation efficiency of blue potato (Solanum tuberosum L. subsp. andigenum). In Vitro Cellular & Developmental Biology - Plant (2020). |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 280.0±23.0 °C at 760 mmHg |
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| Melting Point | 132.5-135.5 °C(lit.) |
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| Molecular Formula | C8H9NO2 |
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| Molecular Weight | 151.163 |
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| Flash Point | 146.8±18.9 °C |
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| Exact Mass | 151.063324 |
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| PSA | 52.32000 |
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| LogP | 0.85 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.546 |
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| InChIKey | VKPLPDIMEREJJF-UHFFFAOYSA-N |
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| SMILES | COc1cccc(C(N)=O)c1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CV5463333
- CHEMICAL NAME :
- Benzamide, 3-methoxy-
- CAS REGISTRY NUMBER :
- 5813-86-5
- BEILSTEIN REFERENCE NO. :
- 2206857
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H9-N-O2
- MOLECULAR WEIGHT :
- 151.18
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 28,335,1994
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | CV5463333 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles25
More Articles
| Characterization of the superinduction of the c-myc proto-oncogene in fibroblasts by benzamide derivatives. Mol. Cell Biochem. 124(2) , 175-81, (1993) In mouse fibroblasts stimulated from quiescence into proliferation by serum the induction of expression of the c-myc proto-oncogene is strongly stimulated by 3-methoxybenzamide. Similar superinduction... | |
| Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor. Int. J. Immunopharmacol. 17(4) , 265-71, (1995) 6(5H)-phenanthridinone, a recently identified poly(ADP-ribose)polymerase (PARP) inhibitor, is able, at micromolar concentrations, to inhibit concanavalin A-induced lymphocyte proliferation and to pote... | |
| Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ. Bioorg. Med. Chem. Lett. 19 , 524-7, (2009) 3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identificat... | |
Synonyms
| 3-Methoxybenzamide |
| MFCD00007986 |
| 3-Methoxy-benzoesaeure-amid |
| 3-Methoxy-benzamid |
| 3-methoxy-benzoic acid amide |
| m-anisamide |
| Benzamide, 3-methoxy- |
| Benzamide,3-methoxy |
| 3-Methoxy-benzamide |
| EINECS 227-379-7 |
| 3-Methoxyphenylformamide |
| m-Methoxybenzamide |
