Introduction：Basic information about CAS 49863-47-0|g418, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | g418 |
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| CAS Number | 49863-47-0 | Molecular Weight | 496.55200 |
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| Density | 1.47 g/cm3 | Boiling Point | 760.3ºC at 760 mmHg |
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| Molecular Formula | C20H40N4O10 | Melting Point | / |
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| MSDS | / | Flash Point | 413.6ºC |
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Names
| Name | geneticin |
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| Synonym | More Synonyms |
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g418 BiologicalActivity
| Description | G-418 (Geneticin) is an aminoglycoside antibiotic with a structure similar to gentamicin. It is toxic to both eukaryotic and prokaryotic cells and works by interfering with protein synthesis[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | G-418 (500 μg/mL，12 days) 用于筛选耐药性 LNCaP 细胞[1]。 |
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| References | [1]. S Bennett, et al. Reliable method of isolating transfected clones from the LNCaP human prostatic cell line. Biotechniques. 1997 Jul;23(1):66, 68, 70. |
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Chemical & Physical Properties
| Density | 1.47 g/cm3 |
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| Boiling Point | 760.3ºC at 760 mmHg |
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| Molecular Formula | C20H40N4O10 |
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| Molecular Weight | 496.55200 |
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| Flash Point | 413.6ºC |
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| Exact Mass | 496.27400 |
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| PSA | 248.39000 |
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| InChIKey | BRZYSWJRSDMWLG-DJWUNRQOSA-N |
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| SMILES | CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(C(C)O)C(O)C(O)C3N)C2O)OCC1(C)O |
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| Storage condition | 2-8°C |
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| Water Solubility | H2O: 50 mg/mL |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WK2132600
- CHEMICAL NAME :
- D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopy ranosyl-(1-4)-O- (3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyr anosyl-(1-6))-
- CAS REGISTRY NUMBER :
- 49863-47-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H40-N4-O10
- MOLECULAR WEIGHT :
- 496.64
- WISWESSER LINE NOTATION :
- T6OTJ CZ DQ EQ FYQ1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DM1 EQ E1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Fibroblast
- DOSE/DURATION :
- 75 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,67,1993
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | 22-24/25 |
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| WGK Germany | 3 |
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Synonyms
| Gentamicin G-418 |
| Gentamycin B |
| (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-[(1R)-1-hydroxyethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol |
| Betamicina [INN-Spanish] |
| Gentamicin B |
| Betamicina |
| BETAMICIN |
| Betamicinum [INN-Latin] |
| Betamicine [INN-French] |
| Betamicin [INN] |
