Introduction：Basic information about CAS 476-69-7|D-Corydine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | D-Corydine |
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| CAS Number | 476-69-7 | Molecular Weight | 341.401 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 505.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H23NO4 | Melting Point | 165-167ºC |
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| MSDS | / | Flash Point | 259.7±30.1 °C |
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Names
| Name | (+)-corydaline |
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| Synonym | More Synonyms |
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D-Corydine BiologicalActivity
| Description | Corydine is a naturally occurring alkaloid which can be extracted from plants such as Croton echinocarpus leaves. Corydine is efficient on inhibiting reverse transcriptase (RT) activity with an IC50 of 356.8 μg/mL. Corydine displays significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 450 μg/mL of Corydine[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Reverse Transcriptase |
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| References | [1]. N.Ravanelli, et al. Alkaloids from Croton echinocarpus Baill.: Anti-HIV potential. South African Journal of Botany. 2016 Jan, 102: 153-156 |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 505.7±50.0 °C at 760 mmHg |
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| Melting Point | 165-167ºC |
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| Molecular Formula | C20H23NO4 |
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| Molecular Weight | 341.401 |
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| Flash Point | 259.7±30.1 °C |
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| Exact Mass | 341.162720 |
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| PSA | 51.16000 |
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| LogP | 3.09 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.604 |
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| InChIKey | IDQUPXZJURZAGF-ZDUSSCGKSA-N |
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| SMILES | COc1cc2c3c(c1O)-c1c(ccc(OC)c1OC)CC3N(C)CC2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CE1057000
- CHEMICAL NAME :
- 6a-alpha-Aporphin-1-ol, 2,10,11-trimethoxy-
- CAS REGISTRY NUMBER :
- 476-69-7
- BEILSTEIN REFERENCE NO. :
- 0095568
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H23-N-O4
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 115 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 31,44,1968
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Synonyms
| 4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (6aS)- |
| 4H-Dibenzo[de,g]quinolin-1-ol, 5,6,6a,7-tetrahydro-2,10,11-trimethoxy-6-methyl-, (S)- |
| (S)-5,6,6a,7-Tetrahydro-2,10.11-trimethoxy-6-methyl-4H-dibenzo[de,q]quinolin-1-ol |
| 2,10,11-Trimethoxy-6aa-aporphin-1-ol |
| d-corydine |
| glaucentrin |
| glaucentrine |
| O11-Methylcorytuberine |
| (6aS)-2,10,11-Trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1-ol |
