Introduction：Basic information about CAS 6404-29-1|Boc-6-aminohexanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-6-aminohexanoic acid |
|---|
| CAS Number | 6404-29-1 | Molecular Weight | 231.289 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 380.3±25.0 °C at 760 mmHg |
|---|
| Molecular Formula | C11H21NO4 | Melting Point | 35-40 °C |
|---|
| MSDS | USA | Flash Point | 183.8±23.2 °C |
|---|
Names
| Name | Boc-6-aminohexanoic acid |
|---|
| Synonym | More Synonyms |
|---|
Boc-6-aminohexanoic acid BiologicalActivity
| Description | Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
|---|
| Target | Alkyl/ether |
|---|
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 380.3±25.0 °C at 760 mmHg |
|---|
| Melting Point | 35-40 °C |
|---|
| Molecular Formula | C11H21NO4 |
|---|
| Molecular Weight | 231.289 |
|---|
| Flash Point | 183.8±23.2 °C |
|---|
| Exact Mass | 231.147064 |
|---|
| PSA | 75.63000 |
|---|
| LogP | 1.67 |
|---|
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
|---|
| Index of Refraction | 1.464 |
|---|
| InChIKey | RUFDYIJGNPVTAY-UHFFFAOYSA-N |
|---|
| SMILES | CC(C)(C)OC(=O)NCCCCCC(=O)O |
|---|
| Storage condition | 2-8°C |
|---|
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|
| Hazard Codes | Xi |
|---|
| Risk Phrases | 36/37/38 |
|---|
| Safety Phrases | S22-S24/25-S26 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
| HS Code | 2924199090 |
|---|
Customs
| HS Code | 2924199090 |
|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Articles4
More Articles
| The literature on affinity chromatography. Meth. Enzymol. 34 , 3, (1974)
| |
| Affinity chromatography of carboxypeptidase B. Meth. Enzymol. 34 , 411, (1974)
| |
| Synthesis and properties of radioiodinated phospholipid analogues that spontaneously undergo vesicle-vesicle and vesicle-cell transfer. Biochemistry 22 , 3617, (1983) An efficient method for the synthesis and purification of a variety of iodinated phospholipid analogues is described. 1-Acyl-2-[[[3-(3-[125I]iodo-4-hydroxyphenyl)- propionyl]amino]caproyl]phosphatidyl... | |
Synonyms
| 6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid |
| 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid |
| 6-[(tert-butoxycarbonyl)amino]hexanoic acid |
| Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]- |
| MFCD00037798 |
| Boc-ε-Acp-OH |
| Boc-ε-Ahx-OH |
