CAS 34391-04-3|Levalbuterol

Introduction：Basic information about CAS 34391-04-3|Levalbuterol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Levalbuterol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Levalbuterol
CAS Number	34391-04-3	Molecular Weight	239.311
Density	1.2±0.1 g/cm3	Boiling Point	433.5±40.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₁NO₃	Melting Point	/
MSDS	/	Flash Point	159.5±17.9 °C

Names

Name	(R)-salbutamol
Synonym	More Synonyms

Levalbuterol BiologicalActivity

Description	Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology
In Vitro	Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2expression in airway epithelial cells[1]. Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line[1]. RT-PCR[1] Cell Line: Murine Club (MTCC) cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased 11β-HSD1 mRNA expression selectively.
In Vivo	Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE[3]. Animal Model: C57BL/6 female mice with a pulmonary allergic model[3] Dosage: 1 mg/kg Administration: Subcutaneous injection; 1 mg/kg; 14 days Result: Decreased pulmonary inflammation after OVA sensitization.
References	[1]. Randall MJ, et al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells.Front Endocrinol (Lausanne). 2015 Jan 12;5:236. [2]. Ferrada MA, et al. (R)-albuterol decreases immune responses: role of activated T cells.Respir Res. 2008 Jan 14;9:3.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	433.5±40.0 °C at 760 mmHg
Molecular Formula	C₁₃H₂₁NO₃
Molecular Weight	239.311
Flash Point	159.5±17.9 °C
Exact Mass	239.152145
PSA	72.72000
LogP	0.01
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.566
InChIKey	NDAUXUAQIAJITI-LBPRGKRZSA-N
SMILES	CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ6426700

CHEMICAL NAME :: 1,3-Benzenedimethanol, alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (-)-

CAS REGISTRY NUMBER :: 34391-04-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H21-N-O3

MOLECULAR WEIGHT :: 239.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 225 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Endocrine - changes in spleen weight

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,106,1996

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

(-)-Albuterol

(R)-albuterol

R-Albuterol

Levosalbutamol

(a1R)-a1-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol

(l)-albuterol

(R)-a1-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-a,a'-diol

1,3-Benzenedimethanol, α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (αR)-

(-)-a1-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol

(R)-salbutamol

4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol

R-Salbutamol

UNII-EDN2NBH5SS

(-)-Salbutamol

Levalbuterol

Albuterol

MFCD00869868

1,3-Benzenedimethanol, α1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (α1R)-

Salbutamol

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