CAS 98206-10-1|(R)-Flesinoxan
Introduction：Basic information about CAS 98206-10-1|(R)-Flesinoxan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R)-Flesinoxan | ||
|---|---|---|---|
| CAS Number | 98206-10-1 | Molecular Weight | 415.45800 |
| Density | 1.271g/cm3 | Boiling Point | 635.8ºC at 760mmHg |
| Molecular Formula | C22H26FN3O4 | Melting Point | / |
| MSDS | / | Flash Point | 338.3ºC |
Names
| Name | 4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide |
|---|---|
| Synonym | More Synonyms |
(R)-Flesinoxan BiologicalActivity
| Description | Flesinoxan is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects[1][2][3]. |
|---|---|
| Target | 5-HT1A Receptor:24 nM (EC50) |
| In Vivo | Flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-HT1A receptors. The capacity of Flesinoxan to antagonize the effect of 5-HT on CA3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT)[1]. The intravenous administration of Flesinoxan suppresses the firing activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons. The acute brain penetration of [3H]Flesinoxan and [3H]8-OH-DPAT are determined. Nine minutes after intravenous administration, [3H]8-OH-DPAT reached significantly greater brain concentration than [3H]Flesinoxan[1]. Subcutaneous administration of Flesinoxan and 8-OH-DPAT produce a dose-dependent hypothermia. The Flesinoxan-induced hypothermia is significantly attenuated by prior administration of the non-selective 5-HT1A antagonist pindolol and the 5-HT1/2 antagonist methysergide. Similar degrees of hypothermia are achieved with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT. The maximal effect of Flesinoxan occurs 30 min later than that of 8-OH-DPAT and fades more slowly[1]. |
| References | [1]. Hadrava V, et al. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 1995 Oct;34(10):1311-26. [2]. Schoeffter P, et al. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br J Pharmacol. 1988 Nov;95(3):975-85. [3]. Rodgers RJ, et al. Antianxiety and behavioral suppressant actions of the novel 5-HT1A receptor agonist, flesinoxan. Pharmacol Biochem Behav. 1994 Aug;48(4):959-63. |
Chemical & Physical Properties
| Density | 1.271g/cm3 |
|---|---|
| Boiling Point | 635.8ºC at 760mmHg |
| Molecular Formula | C22H26FN3O4 |
| Molecular Weight | 415.45800 |
| Flash Point | 338.3ºC |
| Exact Mass | 415.19100 |
| PSA | 74.27000 |
| LogP | 1.90360 |
| Index of Refraction | 1.585 |
| InChIKey | NYSDRDDQELAVKP-SFHVURJKSA-N |
| SMILES | O=C(NCCN1CCN(c2cccc3c2OCC(CO)O3)CC1)c1ccc(F)cc1 |
Synonyms
| unii-8hv9s83fny |
