CAS 37739-05-2|ccpa
| Common Name | ccpa | ||
|---|---|---|---|
| CAS Number | 37739-05-2 | Molecular Weight | 369.80 |
| Density | 1.87g/cm3 | Boiling Point | 617.3ºC at 760mmHg |
| Molecular Formula | C15H20ClN5O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 327.1ºC |
Names
| Name | 2-Chloro-N6-cyclopentyl Adenosine |
|---|---|
| Synonym | More Synonyms |
ccpa BiologicalActivity
| Description | CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
| References | [1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
Chemical & Physical Properties
| Density | 1.87g/cm3 |
|---|---|
| Boiling Point | 617.3ºC at 760mmHg |
| Molecular Formula | C15H20ClN5O4 |
| Molecular Weight | 369.80 |
| Flash Point | 327.1ºC |
| Exact Mass | 369.12000 |
| PSA | 125.55000 |
| LogP | 0.51870 |
| Index of Refraction | 1.824 |
| InChIKey | XSMYYYQVWPZWIZ-IDTAVKCVSA-N |
| SMILES | OCC1OC(n2cnc3c(NC4CCCC4)nc(Cl)nc32)C(O)C1O |
| Storage condition | 2-8°C |
| Water Solubility | H2O: 1.7 mg/mL, insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 44,1305,1994
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7357555 |
Articles50
More Articles| Adenosine receptors and muscarinic receptors cooperate in acetylcholine release modulation in the neuromuscular synapse. Eur. J. Neurosci. 42 , 1775-87, (2015) Adenosine receptors (ARs) are present in the motor terminals at the mouse neuromuscular junction. ARs and the presynaptic muscarinic acetylcholine receptors (mAChRs) share the functional control of th... | |
| Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT. Clin. Microbiol. Infect. 20(11) , O960-8, (2014) Chronic cavitary pulmonary aspergillosis (CCPA) is an uncommon but serious pulmonary disease of humans, with an annual mortality rate of 10-30%. It is caused by the fungus Aspergillus fumigatus. Patie... | |
| Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281. Cell. Signal. 27(5) , 1008-18, (2015) Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemothera... |
Synonyms
| 2-Chloro-N-cyclopentyladenosine |
| 2-Chloro-N6-cyclopentyladenosine |
| 2-Chloro-N6-cyclopentyladenosine,2-Chloro-N-cyclopentyladenosine |
