Introduction：Basic information about CAS 23047-25-8|Lofepramine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lofepramine |
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| CAS Number | 23047-25-8 | Molecular Weight | 418.95800 |
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| Density | 1.173g/cm3 | Boiling Point | 575ºC at 760mmHg |
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| Molecular Formula | C26H27ClN2O | Melting Point | / |
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| MSDS | / | Flash Point | 301.6ºC |
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Names
| Name | lofepramine |
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| Synonym | More Synonyms |
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Lofepramine BiologicalActivity
| Description | Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1]. |
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| Related Catalog | Signaling Pathways >>Others >>Others |
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| References | [1]. Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40. |
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Chemical & Physical Properties
| Density | 1.173g/cm3 |
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| Boiling Point | 575ºC at 760mmHg |
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| Molecular Formula | C26H27ClN2O |
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| Molecular Weight | 418.95800 |
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| Flash Point | 301.6ºC |
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| Exact Mass | 418.18100 |
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| PSA | 23.55000 |
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| LogP | 5.84650 |
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| Vapour Pressure | 3.17E-13mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | SAPNXPWPAUFAJU-UHFFFAOYSA-N |
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| SMILES | CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1 |
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Safety Information
Synonyms
| 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone |
| Lofepramine |
