Introduction：Basic information about CAS 36889-13-1|l-nio dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | l-nio dihydrochloride |
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| CAS Number | 36889-13-1 | Molecular Weight | 173.21 |
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| Density | 1.26 g/cm3 | Boiling Point | 358.9ºC at 760 mmHg |
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| Molecular Formula | C7H15N3O2 | Melting Point | 225-226ºC |
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| MSDS | / | Flash Point | 170.9ºC |
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Names
| Name | L-NIO dihydrochloride,N5-(1-Iminoethyl)-L-ornithinedihydrochloride |
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| Synonym | More Synonyms |
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l-nio dihydrochloride BiologicalActivity
| Description | L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO induces a consistentfocal ischemic infarctin rats[2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NO Synthase |
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| Target | Ki: 1.7 μM (nNOS), 3.9 μM (eNOS), 3.9 μM (iNOS)[1] |
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| In Vitro | L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1]. |
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| In Vivo | L-NIO (2.0 μmol, 3 days post-ischemia) causes focal cerebral ischemia in the adult rat brain[2]. |
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| References | [1]. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. [2]. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57. |
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Chemical & Physical Properties
| Density | 1.26 g/cm3 |
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| Boiling Point | 358.9ºC at 760 mmHg |
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| Melting Point | 225-226ºC |
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| Molecular Formula | C7H15N3O2 |
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| Molecular Weight | 173.21 |
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| Flash Point | 170.9ºC |
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| Exact Mass | 245.069778 |
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| PSA | 99.20000 |
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| LogP | 2.56020 |
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| InChIKey | UYZFAUAYFLEHRC-LURJTMIESA-N |
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| SMILES | CC(N)=NCCCC(N)C(=O)O |
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| Storage condition | -20°C |
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Safety Information
| Safety Phrases | S24/25 |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| L-NIO,2HCL |
| L-NIO DIHYDROCHLORIDE |
| (E)-N-(1-Aminoethylidene)-L-ornithine dihydrochloride |
| L-NIO |
| L-N5-(1-Iminoethyl)-ornithine dihydrochloride |
| L-Ornithine, N-(1-aminoethylidene)-, (E)-, hydrochloride (1:2) |
