Introduction：Basic information about CAS 42373-41-1|ATP dipotassium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ATP dipotassium |
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| CAS Number | 42373-41-1 | Molecular Weight | 583.36200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H14K2N5O13P3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | adenosine 5'-triphosphate potassium salt |
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| Synonym | More Synonyms |
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ATP dipotassium BiologicalActivity
| Description | ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
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| In Vitro | ATP dipotassium (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner[4]. ATP dipotassium stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis[4]. |
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| In Vivo | ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP dipotassium induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection. |
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| References | [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. |
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Chemical & Physical Properties
| Molecular Formula | C10H14K2N5O13P3 |
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| Molecular Weight | 583.36200 |
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| Exact Mass | 582.90800 |
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| PSA | 314.22000 |
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| InChIKey | YFPSRAQDZYNYPX-UHFFFAOYSA-L |
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| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)OP(=O)([O-])[O-])C(O)C1O.[K+].[K+] |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | 26-36 |
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Synonyms
| Adenosintriphosphat,Tetrakaliumsalz |
| 5'-ATP-K2 |
| ADENOSINE-5'-TRIPHOSPHATE DIPOTASSIUM SALT |
| Adenosine 5'-(tetrahydrogen triphosphate),dipotassiuM salt |
| adenosine 5'-triphosphate dipotassium*from bacter |
| MFCD00084672 |
| ADENOSINE 5'-TRIPHOSPHATE DIPOTASSIUMFRO M BACTERIA |
| ATP POTASSIUM SALT |
