CAS 890764-36-0|VU 29
Introduction：Basic information about CAS 890764-36-0|VU 29, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | VU 29 | ||
|---|---|---|---|
| CAS Number | 890764-36-0 | Molecular Weight | 384.38700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C22H16N4O3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | N-(2,5-diphenylpyrazol-3-yl)-4-nitrobenzamide |
|---|---|
| Synonym | More Synonyms |
VU 29 BiologicalActivity
| Description | VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM and Ki=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM)[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
| Target | rat mGluR5:9 nM (EC50) rat mGluR1:557 nM (EC50) rat mGluR2:1.5 μM (EC50) hmGluR4:154 nM (EC50) rat mGluR5:224 nM (Ki) |
| In Vivo | VU-29 (500 nM) potentiates DHPG induced increases in phosphoinositide (PI) hydrolysis in rat hippocampal slices. VU-29 potentiates threshold TBS-induced long term potentiation (LTP) in rat hippocampal CA1 region. VU-29 (1 µM) potentiates chemically induced mGluR-long term depression (LTD) in area CA1 of the rat hippocampus. VU-29 (1 µM) potentiates stimulus-induced NMDA receptor-independent LTD[1]. |
| References | [1]. Ayala JE, et al. mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology. 2009;34(9):2057-2071. [2]. Chen Y, et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol. 2007;71(5):1389-1398. |
Chemical & Physical Properties
| Molecular Formula | C22H16N4O3 |
|---|---|
| Molecular Weight | 384.38700 |
| Exact Mass | 384.12200 |
| PSA | 92.74000 |
| LogP | 5.29600 |
| InChIKey | KIALCSMRIHRFPL-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cc(-c2ccccc2)nn1-c1ccccc1)c1ccc([N+](=O)[O-])cc1 |
Safety Information
| Hazard Codes | Xn |
|---|
Synonyms
| ABT 724 trihydrochloride |
| DPAP |
| VU-29 |
