Introduction：Basic information about CAS 1758-80-1|H-Dab.HBr, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Dab.HBr |
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| CAS Number | 1758-80-1 | Molecular Weight | 118.13 |
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| Density | 1.218 g/cm3 | Boiling Point | 321ºC at 760 mmHg |
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| Molecular Formula | C4H10N2O2 | Melting Point | / |
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| MSDS | / | Flash Point | 147.9ºC |
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Names
| Name | L-2,4-diaminobutyric acid |
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| Synonym | More Synonyms |
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H-Dab.HBr BiologicalActivity
| Description | L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological DiseaseNatural Products >>Others |
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| Target | Human Endogenous Metabolite |
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| In Vitro | The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine[1]. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[3]. |
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| In Vivo | Treatment with L-DABA results in 43.4% reduction of tumor growth[1]. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro[2]. |
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| Animal Admin | Mice: Male Sprague Dawley rats (150-200g) are used in the study. LDABA is dissolved in 09.% saline and diluted in appropriate medium. L-DABA is administered intraperitoneally at a dose of 764 mg/kg in a volume of 4 mL/kg in acute studies. Chronically treated rats receives daily intraperitoneally injections (2.5mM/kg in saline) for 3 days. Mice are sacrificed and the brain regions are dissected for analysis[2]. |
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| References | [1]. Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68. [2]. Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8. [3]. Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. |
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Chemical & Physical Properties
| Density | 1.218 g/cm3 |
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| Boiling Point | 321ºC at 760 mmHg |
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| Molecular Formula | C4H10N2O2 |
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| Molecular Weight | 118.13 |
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| Flash Point | 147.9ºC |
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| PSA | 89.34000 |
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| LogP | 1.10580 |
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| Vapour Pressure | 6.36E-05mmHg at 25°C |
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| Index of Refraction | 1.513 |
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| InChIKey | OGNSCSPNOLGXSM-VKHMYHEASA-N |
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| SMILES | NCCC(N)C(=O)O |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2922499990 |
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Customs
| HS Code | 2922499990 |
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| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| L-DAB HBR |
| MFCD07368664 |
| L-2,4-Diaminobutyric acid hydrobromine |
| (2S)-2,4-Diaminobutanoic acid hydrobromide (1:1) |
| Butanoic acid, 2,4-diamino-, (2S)-, hydrobromide (1:1) |
| L-DABA |
| L-Dab.HBr |
| H-Dab.HBr |
