CAS 37642-65-2|[Hyp<sup>3</sup>]Bradykinin
| Common Name | [Hyp<sup>3</sup>]Bradykinin | ||
|---|---|---|---|
| CAS Number | 37642-65-2 | Molecular Weight | 1076.208 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C50H73N15O12 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | arg-pro-hyp-gly-phe-ser-pro-phe-arg |
|---|---|
| Synonym | More Synonyms |
[Hyp<sup>3</sup>]Bradykinin BiologicalActivity
| Description | [Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Bradykinin Receptor |
| In Vitro | [Hyp3]-Bradykinin is as active as native Bradykinin in its ability to bind to bovine uterine myometrium and in its potency on the isolated rat uterus[1]. |
| References | [1]. R Dengler, et al. [Hyp3]-bradykinin and [Hyp3]-Lys-bradykinin interact with B2-bradykinin receptors and stimulate inositol phosphate production in cultured human fibroblasts. FEBS Lett. 1990 Mar 12;262(1):111-4. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C50H73N15O12 |
| Molecular Weight | 1076.208 |
| Exact Mass | 1075.556274 |
| PSA | 434.01000 |
| LogP | -1.09 |
| Index of Refraction | 1.700 |
| InChIKey | JXRLHZCEMXTCBN-UHFFFAOYSA-N |
| SMILES | NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1CC(O)CC1C(=O)NCC(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles12
More Articles| Bradykinin receptors and their antagonists. Eur. J. Pharmacol. 348 , 1-10, (1998) Bradykinin and related kinins act on two receptor types, named B1 and B2. Initially identified in classical bioassays, these receptors have been cloned and characterized in binding assays performed on... | |
| Bradykinin receptor types and B2 subtypes. Life Sci. 55 , 735-749, (1994) Bradykinin, desArg9BK, some agonist analogues and several antagonists have been tested in isolated organs in order to identify bradykinin B2 receptor subtypes. The initial pharmacological characteriza... | |
| Isolation and identification of hydroxyproline analogues of bradykinin in human urine. FEBS Lett. 232 , 252, (1988) Hydroxyproline (Hyp) analogues of bradykinin and lysyl-bradykinin, in which the third residue of bradykinin, proline, is replaced by hydroxyproline, were isolated from human urine. Their amino acid se... |
Synonyms
| [Hyp(3)]-bradykinin |
| N-(Diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-N-(diaminomethylene)-L-ornithine |
| [HYP3]-BRADYKININ (HUMAN) 2ACOH 3H2O |
| bradykinin,hydroxy-Pro(3) |
| L-Ornithine, N-(diaminomethylene)-L-ornithyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-N-(diaminomethylene)- |
| [HYP3]-BRADYKININ |
| BRADYKININ [HYP3] |
| [HYP3]-BRADYKININ (HUMAN) |
| L-Arg-L-Pro-4-Hydroxy-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH |
| Bradykinin[Hyp3] |
