Introduction：Basic information about CAS 102029-74-3|β-Casomorphin (human), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | β-Casomorphin (human) |
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| CAS Number | 102029-74-3 | Molecular Weight | 863.99500 |
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| Density | 1.299 g/cm3 | Boiling Point | 1239.2ºC at 760 mmHg |
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| Molecular Formula | C44H61N7O11 | Melting Point | / |
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| MSDS | USA | Flash Point | 703.2ºC |
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Names
| Name | β-Casomorphin |
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| Synonym | More Synonyms |
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β-Casomorphin (human) BiologicalActivity
| Description | β-Casomorphin, human is an opioid peptide, acts as an agonist of opioid receptor. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Metabolic DiseasePeptides |
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| Target | Opioid receptor[2] |
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| In Vitro | β-Casomorphin, human (TyrPro-Phe-Val-Glu-Pro-Ile) is also called human B-casein-(51-57), with the sequenceequivalent to bovine B-casein-(60-66) (Tyr-ProPhe-Pro-G]y-Pro-Ile or B-casomorphin-7)[1]. β-Casomorphin, human (100 μM) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC in rat DHE cells, also elevates increased MUC5AC mRNA levels[2]. |
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| Cell Assay | To study the effect of β-Casomorphin, human and DAMGO, cells are seeded in 12-well culture plates. Experiments are performed 3 (DHE cells) or 21 days (HT29-MTX cells) after confluency. Twenty-four hours before the studies, the culture medium is replaced by serum-free medium to starve the cells from serum and to eliminate any interference from extraneous proteins or hormones. The experimental protocol is then the following: the serum-free medium is removed, and the monolayer cultures of DHE or HT29-MTX are washed twice with PBS (37°C). Serum-free medium with or without β-Casomorphin, human or DAMGO is added to the cells and incubated at 37°C for 30 min to 24 h in a humidified atmosphere. μ-Opioid receptor blockade is performed by preincubating the cells with cyprodime for 30 min before agonist addition. The supernatants are then collected, frozen, and stored at 20°C. Cells are processed with trypsin. The cell numbers per well are determined, and total RNA is isolated. All experiments are performed at least three times in triplicate[2]. |
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| References | [1]. Brantl V. Novel opioid peptides derived from human beta-casein: human beta-casomorphins. Eur J Pharmacol. 1984 Oct 30;106(1):213-4. [2]. Zoghbi S, et al. beta-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a mu-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. |
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Chemical & Physical Properties
| Density | 1.299 g/cm3 |
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| Boiling Point | 1239.2ºC at 760 mmHg |
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| Molecular Formula | C44H61N7O11 |
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| Molecular Weight | 863.99500 |
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| Flash Point | 703.2ºC |
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| Exact Mass | 863.44300 |
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| PSA | 277.87000 |
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| LogP | 3.21710 |
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| InChIKey | ADBHAJDGVKLXHK-UHFFFAOYSA-N |
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| SMILES | CCC(C)C(NC(=O)C1CCCN1C(=O)C(CCC(=O)O)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(N)Cc1ccc(O)cc1)C(C)C)C(=O)O |
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| Storage condition | 2-8℃ |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 2-[[1-[2-[[2-[[2-[[1-[2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid |
| β-Casomorphin (1-7), human |
| β-Casomorphin, human |
