CAS 71439-68-4|CL-216942

Introduction：Basic information about CAS 71439-68-4|CL-216942, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CL-216942 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Synonyms

Common Name	CL-216942
CAS Number	71439-68-4	Molecular Weight	434.92500
Density	/	Boiling Point	646.3ºC at 760 mmHg
Molecular Formula	C₂₂H₂₃ClN₈	Melting Point	/
MSDS	ChineseUSA	Flash Point	344.7ºC

Names

Name	9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride
Synonym	More Synonyms

CL-216942 BiologicalActivity

Description	Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Topoisomerase
Target	Topoisomerase[1]
In Vitro	Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences[1]. Bisantrene dihydrochloride is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA[2].
In Vivo	Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma[3]. Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used[3]. Bisantrene dihydrochloride (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection[3]. Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene dihydrochloride toxicity[4].

Chemical & Physical Properties

Boiling Point	646.3ºC at 760 mmHg
Molecular Formula	C₂₂H₂₃ClN₈
Molecular Weight	434.92500
Flash Point	344.7ºC
Exact Mass	434.17300
PSA	97.56000
LogP	2.87100
InChIKey	KINULKKPVJYRON-PVNXHVEDSA-N
SMILES	C(=NNC1=NCCN1)c1c2ccccc2c(C=NNC2=NCCN2)c2ccccc12.Cl.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CA9647000

CHEMICAL NAME :: 9,10-Anthracenedicarboxaldehyde, bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone), dihydrochloride

CAS REGISTRY NUMBER :: 71439-68-4

LAST UPDATED :: 198506

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H22-N8.2Cl-H

MOLECULAR WEIGHT :: 471.44

WISWESSER LINE NOTATION :: L C666J B1UNM- BT5M CN BUTJ& I1UNM- BT5M CN BUTJ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,440,1982

Synonyms

9,10-anthracenedicarboxaldehyde bis<(4,5-dihydro-1H-imidazol-2-yl)hydrazone> dihydrochloride

Bisantrene hydrochloride

Bisantrene dihydrochloride

9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride

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