Introduction：Basic information about CAS 24939-03-5|Polyinosinic-polycytidylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Polyinosinic-polycytidylic acid |
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| CAS Number | 24939-03-5 | Molecular Weight | 671.403 |
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| Density | / | Boiling Point | 851.4ºC at 760 mmHg |
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| Molecular Formula | C19H27N7O16P2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | poly(I:C) |
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| Synonym | More Synonyms |
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Polyinosinic-polycytidylic acid BiologicalActivity
| Description | Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Polyinosinic-polycytidylic acid presents in some viruses, and is therefore commonly used to model the actions of extracellular dsRNA. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>InfectionResearch Areas >>Inflammation/Immunology |
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| References | [1]. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738. [2]. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369. |
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Chemical & Physical Properties
| Boiling Point | 851.4ºC at 760 mmHg |
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| Molecular Formula | C19H27N7O16P2 |
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| Molecular Weight | 671.403 |
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| Exact Mass | 671.098938 |
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| PSA | 377.00000 |
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| Vapour Pressure | 7.7E-31mmHg at 25°C |
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| InChIKey | ACEVNMQDUCOKHT-ZLOOHWKQSA-N |
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| SMILES | Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2O)c(=O)n1.O=c1[nH]cnc2c1ncn2C1OC(COP(=O)(O)O)C(O)C1O |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TR0175000
- CAS REGISTRY NUMBER :
- 24939-03-5
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 15
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 365 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9500 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 220 ug/kg
- TOXIC EFFECTS :
- Vascular - other changes Blood - hemorrhage Nutritional and Gross Metabolic - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 28 mg/kg/28D-I
- TOXIC EFFECTS :
- Vascular - structural changes in vessels Blood - pigmented or nucleated red blood cells
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 8-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 50 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 250 ug/kg
- REFERENCE :
- VVIRAT Voprosy Virusologii. Problems of Virology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: (5),540,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
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Safety Information
| Hazard Codes | Xn |
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| WGK Germany | 3 |
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| RTECS | TR0175000 |
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Synonyms
| Polyinosinicacid-polycytidylicacid |
| Polyinosinic–polycytidylic acid |
| polyri:polyrc |
| polyi:c |
| Poly(I).Poly(C) |
| polycpolyi |
| 5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1) |
| 4-Amino-1-(5-O-phosphonopentofuranosyl)-2(1H)-pyrimidinone - 5'-inosinic acid (1:1) |
| Polyinosinic |
| 2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphonopentofuranosyl)-, compd. with 5'-inosinic acid (1:1) |
