CAS 32795-44-1|N-Acetylprocainamide
| Common Name | N-Acetylprocainamide | ||
|---|---|---|---|
| CAS Number | 32795-44-1 | Molecular Weight | 277.36200 |
| Density | 1.097g/cm3 | Boiling Point | 500ºC at 760mmHg |
| Molecular Formula | C15H23N3O2 | Melting Point | 138-140ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 256.2ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | N-acetylprocainamide |
|---|---|
| Synonym | More Synonyms |
N-Acetylprocainamide BiologicalActivity
| Description | N-Acetylprocainamide is a class III antiarrhythmic, which blocks K+ channels. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelResearch Areas >>Cardiovascular Disease |
| Target | K+ channel[1] |
| In Vitro | N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers[1]. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion[2]. |
| References | [1]. Nakahara T, et al. Role of K+ channels in N-acetylprocainamide-induced relaxation of bovine tracheal smooth muscle. Eur J Pharmacol. 2001 Mar 9;415(1):73-8. [2]. Plass H, et al. Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):492-9. |
Chemical & Physical Properties
| Density | 1.097g/cm3 |
|---|---|
| Boiling Point | 500ºC at 760mmHg |
| Melting Point | 138-140ºC(lit.) |
| Molecular Formula | C15H23N3O2 |
| Molecular Weight | 277.36200 |
| Flash Point | 256.2ºC |
| Exact Mass | 277.17900 |
| PSA | 61.44000 |
| LogP | 2.18050 |
| InChIKey | KEECCEWTUVWFCV-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1 |
| Storage condition | -20°C |
| Water Solubility | soluble1%, clear, colorless to faintly yellow (1N HCl) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 169,156,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3173 No. of Facilities: 71 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 758 (estimated) No. of Female Employees: 361 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | UN 3249 |
| WGK Germany | 3 |
| RTECS | AE1974350 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2924299090 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles31
More Articles| Drug-herb interaction: effect of St John's wort on bioavailability and metabolism of procainamide in mice. Arch. Pathol. Lab. Med. 131(7) , 1094-8, (2007) St John's wort induces the activity of the cytochrome P450 enzyme system causing treatment failure because of increased metabolism of many drugs. Procainamide is metabolized by a different pathway to ... | |
| Application of computer-assisted radiotelemetry in the pharmacokinetic and pharmacodynamic modeling of procainamide and N-acetylprocainamide. J. Pharm. Sci. 85(6) , 595-9, (1996) The cardiovascular pharmacodynamics (PD) of procainamide and N-acetylprocainamide have not been well characterized in small rodents without the presence of anesthesia or restraint. This study was unde... | |
| The discordant influences of infarct healing on the electrophysiologic effects of procainamide and N-acetylprocainamide. J. Pharmacol. Exp. Ther. 273(1) , 315-9, (1995) Ischemic zone refractoriness and conduction delay respond differently to infarct healing and, hypothetically, may exert discordant influences on the electrophysiologic action of different classes of a... |
Synonyms
| NAPA |
| 4-acetamido-N-(2-diethylaminoethyl)benzamide |
| Acecainide [INN] |
| MFCD00009052 |
| 4-acetamido-N-[2-(diethylamino)ethyl]benzamide |
| N-Acetyloprokainamid |
| Acecainidum |
| Acekainid |
| N-Acetylnovocainamide |
| Acekainid [Polish] |
| Acecainide |
| 4-acetylamino-N-(2-diethylamino-ethyl)-benzamide |
| Acecainida |
| N-Acetylprocainamide |
