CAS 778576-62-8|Oglemilast

Introduction：Basic information about CAS 778576-62-8|Oglemilast, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Oglemilast BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Oglemilast
CAS Number	778576-62-8	Molecular Weight	516.30
Density	1.1±0.1 g/cm3	Boiling Point	287.8±40.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₃Cl₂F₂N₃O₅S	Melting Point	/
MSDS	/	Flash Point	136.5±20.6 °C

Names

Name	N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide
Synonym	More Synonyms

Oglemilast BiologicalActivity

Description	Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.IC50 value:Target: PDE4
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology
References	[1]. Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. [2]. Study of Oglemilast for the Prevention of Asthma. [3]. Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD) [4]. Study of Oglemilast for the Treatment of Asthma

Description

Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.IC50 value:Target: PDE4

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology

References

[1]. Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90.

[2]. Study of Oglemilast for the Prevention of Asthma.

[3]. Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)

[4]. Study of Oglemilast for the Treatment of Asthma

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	287.8±40.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₃Cl₂F₂N₃O₅S
Molecular Weight	516.30
Flash Point	136.5±20.6 °C
PSA	118.91000
LogP	1.66
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.562
InChIKey	OKFDRAHPFKMAJH-UHFFFAOYSA-N
SMILES	CS(=O)(=O)Nc1ccc2oc3c(OC(F)F)ccc(C(=O)Nc4c(Cl)cncc4Cl)c3c2c1
Storage condition	2-8℃

Synonyms

Oglemilast [INN]

N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide

Oglemilast

UNII-67GXQ6WCC6

4-Methoxy-2-indanamine

1H-Inden-2-amine, 2,3-dihydro-4-methoxy-

GRC3886

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