CAS 58020-43-2|HOKU-81

Introduction：Basic information about CAS 58020-43-2|HOKU-81, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. HOKU-81 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	HOKU-81
CAS Number	58020-43-2	Molecular Weight	243.73000
Density	1.184g/cm3	Boiling Point	392ºC at 760mmHg
Molecular Formula	C₁₂H₁₈ClNO₂	Melting Point	/
MSDS	/	Flash Point	190.9ºC

Names

Name	hoku-81
Synonym	More Synonyms

HOKU-81 BiologicalActivity

Description	HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. IC50 Value: Target: Adrenergic ReceptorEffects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Cardiovascular Disease
References	[1]. Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8. [2]. Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24.

Description

HOKU-81, a new bronchodilator, is one of the metabolites of tulobuterol. IC50 Value: Target: Adrenergic ReceptorEffects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Cardiovascular Disease

References

[1]. Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8.

[2]. Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24.

Chemical & Physical Properties

Density	1.184g/cm3
Boiling Point	392ºC at 760mmHg
Molecular Formula	C₁₂H₁₈ClNO₂
Molecular Weight	243.73000
Flash Point	190.9ºC
Exact Mass	243.10300
PSA	52.49000
LogP	2.85800
Index of Refraction	1.556
InChIKey	LIXBJWRFCNRAPA-UHFFFAOYSA-N
SMILES	CC(C)(C)NCC(O)c1ccc(O)cc1Cl
Storage condition	2-8℃

Synonyms

2-tert-butylfluorenone

2-tert.-Butylfluorenon

2-tert-butyl-9-fluorenone

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