CAS 58944-73-3|Sinefungin

Introduction：Basic information about CAS 58944-73-3|Sinefungin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sinefungin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles7
7. Synonyms

Common Name	Sinefungin
CAS Number	58944-73-3	Molecular Weight	381.39
Density	1.9±0.1 g/cm3	Boiling Point	783.2±70.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₃N₇O₅	Melting Point	/
MSDS	ChineseUSA	Flash Point	427.5±35.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	sinefungin
Synonym	More Synonyms

Sinefungin BiologicalActivity

Description	Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation [2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Epigenetics >>Histone MethyltransferaseResearch Areas >>Inflammation/Immunology
References	[1]. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7. [2]. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

Description

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation [2].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Epigenetics >>Histone MethyltransferaseResearch Areas >>Inflammation/Immunology

References

[1]. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

[2]. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15.

Chemical & Physical Properties

Density	1.9±0.1 g/cm3
Boiling Point	783.2±70.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₃N₇O₅
Molecular Weight	381.39
Flash Point	427.5±35.7 °C
Exact Mass	381.176056
PSA	208.65000
LogP	-1.33
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.832
InChIKey	LMXOHSDXUQEUSF-YECHIGJVSA-N
SMILES	Nc1ncnc2c1ncn2C1OC(CC(N)CCC(N)C(=O)O)C(O)C1O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HE3140000

CHEMICAL NAME :: D-glycero-alpha-L-talo-Decofuranuronic acid, 6,9-diamino-1-(6-amino-9H-purin-9-yl)- 1,5,6,7,8,9-hexadeoxy-

CAS REGISTRY NUMBER :: 58944-73-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H23-N7-O5

MOLECULAR WEIGHT :: 381.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,298,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,463,1973

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
RTECS	HE3140000

Articles7

Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.

Br. J. Pharmacol. 172(3) , 857-68, (2015)

AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB...

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

Mol. Cancer Ther. 8 , 1579-1588, (2009)

DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore imp...

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

FEBS J. 277(9) , 2096-108, (2010)

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethyla...

Synonyms

(2S,5S)-2,5-Diamino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid (non-preferred name)

Sinefungin

D-Glycero-α-L-talo-Decofuranuronic acid, 6,9-diamino-1- (6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-

6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-a-L-talo-decofuranuronic Acid

Antibiotic 32232RP

(5S)-5-Amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-L-norleucine

(5S)-5-Amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]-L-norleucine

UNII:W2U467CIIL

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