CAS 78950-78-4|8-OH-DPAT
| Common Name | 8-OH-DPAT | ||
|---|---|---|---|
| CAS Number | 78950-78-4 | Molecular Weight | 247.37600 |
| Density | / | Boiling Point | 372.5ºC at 760 mmHg |
| Molecular Formula | C16H25NO | Melting Point | / |
| MSDS | USA | Flash Point | 168.2ºC |
Names
| Name | 8-hydroxy-2-(di-n-propylamino)tetralin |
|---|---|
| Synonym | More Synonyms |
8-OH-DPAT BiologicalActivity
| Description | 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Neurological Disease |
| Target | pIC50: 8.19 (5-HT1A)[1] Ki: 466 nM (5-HT7)[2] |
| In Vitro | 8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5)[1]. 8-OH-DPAT has high affinity at 5-HT7 with a Ki of 466 nM, and does not bind to 5-HT6 or 5-HT4[2]. |
| In Vivo | 8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3]. |
| Animal Admin | Mice[3] The locomotor activity of mice is measured by an infrared sensor placed in individual home cages. To compare the locomotor activity in the light and dark periods, locomotor activity is monitored at 30-min intervals starting at 8:00 a.m. and 8:00 p.m., respectively. To measure the effects of psychostimulants (8-OH-DPAT, 1, 3 mg/kg, s.c; etc.) on locomotor activity in the dark period, all drugs are administered at 8:00 p.m., and locomotor activity is then measured through 3 h[3]. |
| References | [1]. DEREK N. MIDDLEMISS, et al. 8-HYDROXY-2-(DI-n-PROPYLAMINO)-TETRALIN DISCRIMINATES BETWEEN SUBTYPES OF [2]. Bard JA, et al. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. [3]. Mori T, et al. Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT. Psychopharmacology (Berl). 2016 Jun;233(12):2343-53. |
Chemical & Physical Properties
| Boiling Point | 372.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C16H25NO |
| Molecular Weight | 247.37600 |
| Flash Point | 168.2ºC |
| Exact Mass | 247.19400 |
| PSA | 23.47000 |
| LogP | 3.37150 |
| InChIKey | ASXGJMSKWNBENU-UHFFFAOYSA-N |
| SMILES | CCCN(CCC)C1CCc2cccc(O)c2C1 |
| Storage condition | -20℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
Articles35
More Articles| Serotonin 5-HT1A receptor in infancy-onset aggression: comparison with genetically defined aggression in adult rats. Behav. Brain Res. 243 , 97-101, (2013) Antisocial aggressive behavior in adolescents represents growing clinical and social problem. Previously the implication of 5-HT1A receptor in the regulation of fear-induced aggression was shown. Here... | |
| Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT(1A) receptor stimulation in the rat. Neurochem. Int. 61(8) , 1344-56, (2012) This study examined the firing rate and pattern of electrophysiologically and chemically identified GABA interneurons in the dorsal raphe nucleus (DRN), and role of 5-HT(1A) receptor agonist 8-OH-DPAT... | |
| Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus. J. Physiol. Sci. 63(2) , 147-54, (2013) The dorsal raphe nucleus (DRN) is the origin of the central serotonin [5-hydroxytryptamine (5-HT)] system and plays an important role in the regulation of many physiological functions such as sleep/ar... |
Synonyms
| 2-dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene |
| (+/-)-2-dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene |
| (+/-)-2-dirpopylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene |
| 8-OH-2-(di-n-propylamino)-1,2,3,4-tetrahydronaphthalene |
| 3-(Dipropylamino)Tetralin-5-Ol |
| 8-OH-DPAT |
