Introduction：Basic information about CAS 77472-98-1|Pipequaline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pipequaline |
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| CAS Number | 77472-98-1 | Molecular Weight | 316.43900 |
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| Density | 1.078g/cm3 | Boiling Point | 489.2ºC at 760 mmHg |
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| Molecular Formula | C22H24N2 | Melting Point | / |
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| MSDS | / | Flash Point | 249.7ºC |
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Names
| Name | 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline |
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| Synonym | More Synonyms |
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Pipequaline BiologicalActivity
| Description | Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological Disease |
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| In Vitro | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
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| In Vivo | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
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| Animal Admin | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
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| References | [1]. Essassi D, et al. Pipequaline transport from blood to brain and liver: role of plasma protein-bound drug. J Pharm Pharmacol. 1989 Sep;41(9):595-600. [2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. [3]. File SE., et al. Sedative effects of PK 9084 and PK 8165, alone and in combination with chlordiazepoxide. Br J Pharmacol. 1983 May;79(1):219-23. |
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Chemical & Physical Properties
| Density | 1.078g/cm3 |
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| Boiling Point | 489.2ºC at 760 mmHg |
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| Molecular Formula | C22H24N2 |
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| Molecular Weight | 316.43900 |
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| Flash Point | 249.7ºC |
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| Exact Mass | 316.19400 |
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| PSA | 24.92000 |
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| LogP | 5.16280 |
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| Index of Refraction | 1.602 |
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| InChIKey | AMEWZCMTSIONOX-UHFFFAOYSA-N |
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| SMILES | c1ccc(-c2cc(CCC3CCNCC3)c3ccccc3n2)cc1 |
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| Storage condition | 2-8℃ |
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Synonyms
| Pipequalina |
| Pipequalina [Spanish] |
| Pipequalinum [Latin] |
| Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl) |
| 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline |
| 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline |
| Pipequalinum |
| PK-8165 |
| Pipequaline |
