CAS 563-12-2|ethion

Introduction：Basic information about CAS 563-12-2|ethion, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Articles28
6. Synonyms

Common Name	ethion
CAS Number	563-12-2	Molecular Weight	384.476
Density	1.3±0.1 g/cm3	Boiling Point	401.2±55.0 °C at 760 mmHg
Molecular Formula	C₉H₂₂O₄P₂S₄	Melting Point	3ºC
MSDS	ChineseUSA	Flash Point	196.5±31.5 °C
Symbol	GHS06, GHS09	Signal Word	Danger

Names

Name	ethion
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	401.2±55.0 °C at 760 mmHg
Melting Point	3ºC
Molecular Formula	C₉H₂₂O₄P₂S₄
Molecular Weight	384.476
Flash Point	196.5±31.5 °C
Exact Mass	383.987610
PSA	171.32000
LogP	5.07
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.558
InChIKey	RIZMRRKBZQXFOY-UHFFFAOYSA-N
SMILES	CCOP(=S)(OCC)SCSP(=S)(OCC)OCC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TE4550000

CHEMICAL NAME :: Phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester

CAS REGISTRY NUMBER :: 563-12-2

BEILSTEIN REFERENCE NO. :: 1804530

LAST UPDATED :: 199712

DATA ITEMS CITED :: 35

MOLECULAR FORMULA :: C9-H22-O4-P2-S4

MOLECULAR WEIGHT :: 384.49

WISWESSER LINE NOTATION :: 2OPS&O2&S1SPS&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 15700 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: TXMDAX Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd., Austin, TX 78701) V.60- 1964- Volume(issue)/page/year: 63,71,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,286,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933- Volume(issue)/page/year: 185,361,1960

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 864 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C128,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,515,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 129,699,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,367,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 129,699,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 915 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 675 mg/kg/90D-C

TOXIC EFFECTS :: Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,173,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 182 mg/kg/1Y-C

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 8,173,1988 *** REVIEWS *** ACGIH TLV-TWA 0.4 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.4 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.4 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.4 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.4 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.4 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHION-air:10H TWA 0.4 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84542 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 72 (estimated)

Safety Information

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H312-H410
Precautionary Statements	P273-P280-P301 + P310 + P330-P302 + P352 + P312-P391-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T;N
Risk Phrases	R21;R25;R50/53
Safety Phrases	25-36/37-45-60-61-23
RIDADR	3018
WGK Germany	1
RTECS	TE4550000
Packaging Group	II
Hazard Class	6.1(a)

Articles28

Ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to identify contaminants in water: an insight on environmental forensics.

J. Chromatogr. A. 1345 , 86-97, (2014)

Ultra-high pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QqTOF-MS) acquiring full scan MS data for quantification, and automatic data dependent information product ...

Fast agitated directly suspended droplet microextraction technique for the rapid analysis of eighteen organophosphorus pesticides in human blood.

J. Chromatogr. A. 1377 , 27-34, (2015)

A new sample preparation technique named as fast agitated directly suspended droplet microextraction (FA-DSDME) was proposed as an improved version of directly suspended droplet microextraction (DSDME...

Development of a more specific and accurate multiple reaction monitoring method based on GC-EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 47-54, (2015)

A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC-EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, rep...

Synonyms

Etilon

MFCD00036232

Phosphorodithioic Acid S,S'-Methylene O,O,O',O'-Tetraethyl Ester

dithiophosphoric acid S,S'-methanediyl ester tetra-O-ethyl ester

Itopaz

Bis(dithiophosphate) de O,O,O',O'-tétraéthyle et de S,S'-méthylène

Kwit

Ethodan

O,O,O’,O’-tetraethyl S,S’-methylene bis(phosphorodithioate)

ethion

O,O,O',O'-Tetraethyl S,S'-Methylenediphosphorodithioate

bis-diethoxythiophosphorylsulfanyl-methane

Ethanox

O,O,O',O'-Tetraethyl S,S'-methylene bis(phosphorodithioate)

O,O,O,O-tetraethyl-S,S-methylenebisdithiophosphate

S,S’-methylene bis(O,O-diethyl phosphorodithioate)

O,O,O',O'-Tetraethyl-S,S'-methylenbis(dithiophosphat)

ETHIOL

Phosphorodithioic acid, O,O,O',O'-tetraethyl S,S'-methylene ester

rp8167

O,O,O',O'-tetraethyl S,S'-methanediyl bis(phosphorodithioate)

EINECS 209-242-3

Bis[S-(diethoxyphosphinothioyl)mercapto]methane

Ethopaz

O,O,O',O'-tetraethyl S,S'-methylene bis(dithiophosphate)

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