CAS 78-95-5|Chloroacetone
Introduction：Basic information about CAS 78-95-5|Chloroacetone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Chloroacetone | ||
|---|---|---|---|
| CAS Number | 78-95-5 | Molecular Weight | 92.524 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 120.0±8.0 °C at 760 mmHg |
| Molecular Formula | C3H5ClO | Melting Point | -44.5 °C |
| MSDS | ChineseUSA | Flash Point | 27.8±0.0 °C |
| Symbol | GHS02, GHS06, GHS09 | Signal Word | Danger |
Names
| Name | chloroacetone |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 120.0±8.0 °C at 760 mmHg |
| Melting Point | -44.5 °C |
| Molecular Formula | C3H5ClO |
| Molecular Weight | 92.524 |
| Flash Point | 27.8±0.0 °C |
| Exact Mass | 92.002892 |
| PSA | 17.07000 |
| LogP | 0.43 |
| Vapour Pressure | 15.5±0.2 mmHg at 25°C |
| Index of Refraction | 1.397 |
| InChIKey | BULLHNJGPPOUOX-UHFFFAOYSA-N |
| SMILES | CC(=O)CCl |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. May discolour on exposure to light. STENCH. |
| Water Solubility | 124 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 605 ppm/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 262 ppm/1H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 127 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 92 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 141 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 100 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 650 mg/kg/17D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - gastritis Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA - TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 100 pph/6M
- REFERENCE :
- PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74. Volume(issue)/page/year: 62,284,1946/1947 *** REVIEWS *** ACGIH TLV-CL 3.8 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5194 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 100 pph/6M
- REFERENCE :
- PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74. Volume(issue)/page/year: 62,284,1946/1947 *** REVIEWS *** ACGIH TLV-CL 3.8 mg/m3 (1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5194 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
Safety Information
| Symbol | GHS02, GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H226-H301-H310 + H330-H315-H319-H335-H410 |
| Precautionary Statements | P260-P273-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T+:Verytoxic;N:Dangerous for the environment; |
| Risk Phrases | R10;R24/25;R26;R36/37/38;R50/53 |
| Safety Phrases | S16-S23-S36/37/39-S45-S60-S61-S38-S28A-S26 |
| RIDADR | UN 1695 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | UC0700000 |
| Packaging Group | I |
| Hazard Class | 6.1 |
Articles31
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| [Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. VI. 4-(o-tolyl)-thiosemicarbazide of o-nitro - and p-nitrobenzoic acid]. Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 195-202, (1996) The reactions of 4-(o-tolyl)-thiosemicarbazide of o-nitro- and p-nitrobenzoic acid (Ik, l) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanolic... | |
| [Reactions of 1-(X-benzoyl)-4-R-thiosemicarbazide with chloroacetone and omega-bromoacetophenone. V. 4-(o-tolyl)-thiosemicarbazide of of o-chloro- and p-chlorobenzoic acid]. Ann. Univ. Mariae Curie. Sklodowska. Med. 51 , 185-93, (1996) The reactions of 4-(o-tolyl)-thiosemicarbazide of o-chloro- and p-chlorobenzoic acid (Ii, j) with chloroacetone and omega-bromoacetophenone were investigated in: methanolic medium (method D); methanol... |
Synonyms
| Tonite |
| MFCD00000936 |
| Chloro acetone |
| 1-Chloroacetone |
| Chloropropanone |
| 2-Propanone,1-chloro |
| Chloroacetone |
| Acetonyl chloride |
| Chloracetone |
| 2-Propanone, 1-chloro- |
| 1-chloro-propan-2-one |
| α-Chloroacetone |
| Monochloracetone |
| EINECS 201-161-1 |
| 1-chloropropanone |
| 1-chloropropan-2-one |
