CAS 928-51-8|4-Chloro-1-butanol

Introduction：Basic information about CAS 928-51-8|4-Chloro-1-butanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles2
7. Synonyms

Common Name	4-Chloro-1-butanol
CAS Number	928-51-8	Molecular Weight	108.567
Density	1.0±0.1 g/cm3	Boiling Point	178.5±0.0 °C at 760 mmHg
Molecular Formula	C₄H₉ClO	Melting Point	/
MSDS	ChineseUSA	Flash Point	77.2±18.0 °C
Symbol	GHS02, GHS05, GHS07, GHS08	Signal Word	Warning

Names

Name	4-chlorobutanol
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	178.5±0.0 °C at 760 mmHg
Molecular Formula	C₄H₉ClO
Molecular Weight	108.567
Flash Point	77.2±18.0 °C
Exact Mass	108.034195
PSA	20.23000
LogP	0.85
Vapour Pressure	0.3±0.7 mmHg at 25°C
Index of Refraction	1.434
InChIKey	HXHGULXINZUGJX-UHFFFAOYSA-N
SMILES	OCCCCCl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EL1325000

CHEMICAL NAME :: 1-Butanol, 4-chloro-

CAS REGISTRY NUMBER :: 928-51-8

BEILSTEIN REFERENCE NO. :: 1731408

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H9-Cl-O

MOLECULAR WEIGHT :: 108.58

WISWESSER LINE NOTATION :: Q4G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 990 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Gastrointestinal - ulceration or bleeding from stomach Liver - other changes

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 26,17,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 21,739,1956 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3650 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,391,1979

Safety Information

Symbol	GHS02, GHS05, GHS07, GHS08
Signal Word	Warning
Hazard Statements	H226-H290-H302-H315-H319-H335-H351
Precautionary Statements	P210-P280-P301 + P312 + P330-P305 + P351 + P338-P370 + P378
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R10;R20/21/22;R36/37/38
Safety Phrases	S23-S24/25-S36/37/39-S26-S16
RIDADR	UN 2920 8/PG 2
WGK Germany	3
RTECS	EL1325000
Packaging Group	III
Hazard Class	3.2
HS Code	29055910

Customs

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles2

Reichardt's dye and its reactions with the alkylating agents 4-chloro-1-butanol, ethyl methanesulfonate, 1-bromobutane and Fast Red B - a potentially useful reagent for the detection of genotoxic impurities in pharmaceuticals.

J. Pharm. Pharmacol. 61(4) , 533-7, (2009)

Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug producti...

Development and validation of a sensitive GC-MS method for the determination of alkylating agent, 4-chloro-1-butanol, in active pharmaceutical ingredients.

Chem. Pharm. Bull. 62(4) , 395-8, (2014)

The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefo...

Synonyms

4-CHLOROBUTANOL

4-Chloro-1-butanol

1-Butanol,4-chloro

MFCD00002967

4-Choro-1-bytanol

4-Chlorobutane-1-ol

EINECS 213-175-5

4-Chlorolbutanol

1-chlorobutanol

tetramethylene chlorohydrin

4-Chlorobutan-1-ol

4-CHLOROBUTANOL-1

4-Chlorbutan-1-ol

1-Butanol, 4-chloro-

hydroxypropyl methyl chloride

4-chloro-1-butano

4-hydroxybutyl chloride

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