CAS 58306-30-2|Febantel

Introduction：Basic information about CAS 58306-30-2|Febantel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Febantel BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles25
7. Synonyms

Common Name	Febantel
CAS Number	58306-30-2	Molecular Weight	446.477
Density	1.3±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₀H₂₂N₄O₆S	Melting Point	129-130ºC
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	Febantel
Synonym	More Synonyms

Febantel BiologicalActivity

Description	Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.
Related Catalog	Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection

Description

Febantel is an anthelmintic for veterinary use on dogs, cats, cattle, sheep, goats, pig and poultry against roundworms and tapeworms.Target: anthelmintic compoundFebantel is a veteran anthelmintic (wormer) compound belonging to the chemical class of the benzimidazoles, but is a so-called pro-benzimidazole, i.e. it is transformed into a benzimidazole once it gets into the host's organism. Febantel it is transformed into fenbendazole in the stomach and the intestine of the host, shortly after ingestion. Once transformed its behavior is comparable to the one of fenbendazole.

Related Catalog

Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Melting Point	129-130ºC
Molecular Formula	C₂₀H₂₂N₄O₆S
Molecular Weight	446.477
Exact Mass	446.126007
PSA	152.65000
LogP	2.36
Index of Refraction	1.598

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FB3955000

CHEMICAL NAME :: Carbamic acid, ((2-((methoxyacetyl)amino)-4-(phenylthio)phenyl)carbo nimidoyl)bis-, dimethyl ester

CAS REGISTRY NUMBER :: 58306-30-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H22-N4-O6-S

MOLECULAR WEIGHT :: 446.52

WISWESSER LINE NOTATION :: 1OVNUYMVO1&MR DSR& BMV1O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10605 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,2193,1978

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
RIDADR	NONH for all modes of transport
RTECS	FB3955000

Articles25

Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species.

J. Feline Med. Surg. 8(1) , 7-13, (2006)

This study evaluated the effect of two combination products containing febantel, pyrantel, and praziquantel (FPP) for the treatment of Giardia species in experimentally infected kittens. In experiment...

Efficacy of pyrantel embonate, febantel and praziquantel against Giardia species in naturally infected adult dogs.

Vet. Rec. 150(6) , 184-6, (2002)

Rapid determination of the antiparasitic drugs flubendazole and febantel in feeds by HPLC with ultraviolet detection.

J. Pharm. Biomed. Anal. 38(2) , 375-9, (2005)

A rapid and very effective analytical procedure for the simultaneous HPLC determination of two anthelmintics, Flubendazole (FLUB) and Febantel (FEBA), in swine and poultry feeds was developed and test...

Synonyms

{(Z)-({2-[(Méthoxyacétyl)amino]-4-(phénylsulfanyl)phényl}amino)[(méthoxycarbonyl)amino]méthylène}carbamate de méthyle

Dimethyl [[2-(2-Methoxyacetamido)-4-(phenylthio)phenyl]imidocarbonyl]dicarbamate

Carbamic acid, N,N'-[[2-[(2-methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]bis-, dimethyl ester

Dimethyl [({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)methylylidene]biscarbamate

Methyl-[N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamat

Bay h 5757

FEBANTEL PESTANAL

Febantel

Methyl {(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylene}carbamate

rintal

methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate (non-preferred name)

EINECS 261-205-0

[[2-[(Methoxyacetyl)amino]-4-(phenylthio)phenyl]carbonimidoyl]biscarbamic Acid Dimethyl Ester

Methyl-{(Z)-({2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}amino)[(methoxycarbonyl)amino]methylen}carbamat

Bay h-5757

MFCD01738527

bayvh5757

Methyl [N'-{2-[(methoxyacetyl)amino]-4-(phenylsulfanyl)phenyl}-N-(methoxycarbonyl)carbamimidoyl]carbamate

2-Acetamido-5-nitrothiazole VETRANAL

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