CAS 65-46-3|Cytidine
Introduction：Basic information about CAS 65-46-3|Cytidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cytidine | ||
|---|---|---|---|
| CAS Number | 65-46-3 | Molecular Weight | 243.217 |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 529.7±60.0 °C at 760 mmHg |
| Molecular Formula | C9H13N3O5 | Melting Point | 210-220 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 274.1±32.9 °C |
Names
| Name | Cytidine |
|---|---|
| Synonym | More Synonyms |
Cytidine BiologicalActivity
| Description | Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Target: Nucleoside antimetabolite/analogCytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. Cytidine is a component of RNA. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content, such as organ meats, Brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact. In humans, dietary cytidine is converted into uridine, which is probably the compound behind cytidine's metabolic effects.There are a variety of cytidine analogs with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen, and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogNatural Products >>AlkaloidResearch Areas >>Cancer |
| Target | Human Endogenous Metabolite |
| References | [1]. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. 2001;45(6):235-54. [2]. Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000 Oct 1;60(7):989-92. |
Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.7±60.0 °C at 760 mmHg |
| Melting Point | 210-220 °C (dec.)(lit.) |
| Molecular Formula | C9H13N3O5 |
| Molecular Weight | 243.217 |
| Flash Point | 274.1±32.9 °C |
| Exact Mass | 243.085526 |
| PSA | 130.83000 |
| LogP | -1.78 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.756 |
| InChIKey | UHDGCWIWMRVCDJ-XVFCMESISA-N |
| SMILES | Nc1ccn(C2OC(CO)C(O)C2O)c(=O)n1 |
| Water Solubility | SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 150 umol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 150 umol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F+ |
| Risk Phrases | R68 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UW7370000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine |
| EINECS 200-610-9 |
| 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone |
| 2(1H)-Pyrimidinone, 4-amino-1-β-D-ribofuranosyl- |
| 1-β-D-Ribofuranosylcytosine |
| 4-Amino-1-β-δ-ribofuranosyl-2(1H)-pyrimidinone |
| 4-Amino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-on |
| MFCD02181091 |
| Cytidine |
| 4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone |
| Cyd |
| Cytidin |
| 1-β-D-ribofuranosyl-Cytosine |
| Citidine |
| 1-(b-δ-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine |
| Cytosine, 1-β-D-ribofuranosyl- |
| d-cytidine |
| 1-β-δ-Ribofuranosylcytosine |
| CYTIDINE extrapure |
| 1-b-D-Ribofuranosylcytosine |
| 2-Pyrimidinol, 1,4-dihydro-4-imino-1-β-D-ribofuranosyl- |
| 4-Imino-1-(β-D-ribofuranosyl)-1,4-dihydro-2-pyrimidinol |
