Introduction：Basic information about CAS 64838-55-7|Captopril EP Impurity J, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Captopril EP Impurity J |
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| CAS Number | 64838-55-7 | Molecular Weight | 259.322 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 464.8±40.0 °C at 760 mmHg |
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| Molecular Formula | C11H17NO4S | Melting Point | 76-82 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 234.9±27.3 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | N-[3-(Acetylthio)-(2S)-methylpropionyl]-L-proline hydrate |
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| Synonym | More Synonyms |
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Captopril EP Impurity J BiologicalActivity
| Description | Captopril EP Impurity J is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Li, Hp, et al. Synthesis and characterization of captopril derivatives. Res Chem Intermed 39, 621–629 (2013). [2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 464.8±40.0 °C at 760 mmHg |
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| Melting Point | 76-82 °C(lit.) |
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| Molecular Formula | C11H17NO4S |
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| Molecular Weight | 259.322 |
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| Flash Point | 234.9±27.3 °C |
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| Exact Mass | 259.087830 |
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| PSA | 99.98000 |
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| LogP | 0.40 |
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| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
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| Index of Refraction | 1.549 |
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| InChIKey | ZNQRGUYIKSRYCI-APPZFPTMSA-N |
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| SMILES | CC(=O)SCC(C)C(=O)N1CCCC1C(=O)O |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H319 |
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| Precautionary Statements | P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| Risk Phrases | 36 |
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| Safety Phrases | S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 265-250-7 |
| MFCD00792449 |
| (S)-3-Acetylthio-2-methylpropionyl-L-proline |
| L-Proline, 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]- |
| 1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-proline |
| (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline |
