Introduction：Basic information about CAS 928774-43-0|PF-3716556, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PF-3716556 |
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| CAS Number | 928774-43-0 | Molecular Weight | 394.467 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C22H26N4O3 | Melting Point | 143-145°C |
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| MSDS | USA | Flash Point | / |
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Names
| Name | N-(2-hydroxyethyl)-N,2-dimethyl-8-[[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino]imidazo[1,2-a]pyridine-6-carboxamide |
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| Synonym | More Synonyms |
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PF-3716556 BiologicalActivity
| Description | PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase) antagonist, with pIC50 value of 6.009.IC50 value:6.009 (pIC50)Target: H+,K+ ATPasePF-03716556 inhibited the activity of H+, K+-ATPase with pIC50 of 6.026 ± 0.112, 6.038 ± 0.039 and 6.009 ± 0.209 at pH 6.4 for porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 (PF03716556) is useful for treatment of gastroesophageal reflux disease. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Potassium ChannelResearch Areas >>Metabolic Disease |
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| References | [1]. Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]py ridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Melting Point | 143-145°C |
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| Molecular Formula | C22H26N4O3 |
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| Molecular Weight | 394.467 |
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| Exact Mass | 394.200500 |
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| PSA | 79.10000 |
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| LogP | 2.60 |
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| Appearance of Characters | white to tan |
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| Index of Refraction | 1.651 |
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| InChIKey | YBHKBMJREUZHOV-QGZVFWFLSA-N |
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| SMILES | Cc1cn2cc(C(=O)N(C)CCO)cc(NC3CCOc4cccc(C)c43)c2n1 |
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| Storage condition | Refrigerator |
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| Water Solubility | DMSO: ≥10mg/mL |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl- |
| N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide |
| PF 03716556 |
| PF03716556 |
| PF-3716556 |
