CAS 645-35-2|Histidine hydrochloride

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MS3116100

CHEMICAL NAME :

Histidine, monohydrochloride, L-

CAS REGISTRY NUMBER :

645-35-2

LAST UPDATED :

199706

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C6-H9-N3-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4407 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

697 gm/kg/2Y-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,687,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82261 No. of Facilities: 59 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82261 No. of Facilities: 196 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 2601 (estimated) No. of Female Employees: 1791 (estimated)

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