CAS 64-02-8|Sodium edetate
Introduction：Basic information about CAS 64-02-8|Sodium edetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium edetate | ||
|---|---|---|---|
| CAS Number | 64-02-8 | Molecular Weight | 380.17 |
| Density | 6.9 g/cm3 | Boiling Point | 614.2ºC at 760 mmHg |
| Molecular Formula | C10H12N2Na4O8 | Melting Point | >300 °C(lit.) |
| MSDS | Chinese | Flash Point | 325.2ºC |
Names
| Name | EDTA tetrasodium |
|---|---|
| Synonym | More Synonyms |
Sodium edetate BiologicalActivity
| Description | Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can also decrease the formation of disulfide bonds[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Others |
| References | [1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9. [2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76. [3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62. |
Chemical & Physical Properties
| Density | 6.9 g/cm3 |
|---|---|
| Boiling Point | 614.2ºC at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C10H12N2Na4O8 |
| Molecular Weight | 380.17 |
| Flash Point | 325.2ºC |
| Exact Mass | 380.018433 |
| PSA | 167.00000 |
| InChIKey | UEUXEKPTXMALOB-UHFFFAOYSA-J |
| SMILES | O=C([O-])CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Na+].[Na+] |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | H2O: 0.1 g/mL, clear, colorless |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AAOPAF AMA Archives of Ophthalmology. (Chicago, IL) V.44(4)-63, 1950-60. For publisher information, see AROPAW. Volume(issue)/page/year: 48,681,1952
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,306,1972 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 330 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique. (Masson Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France) V.1- 1953- Volume(issue)/page/year: 10,391,1962 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80223 No. of Facilities: 49290 (estimated) No. of Industries: 218 No. of Occupations: 128 No. of Employees: 584676 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80223 No. of Facilities: 55714 (estimated) No. of Industries: 293 No. of Occupations: 186 No. of Employees: 1388281 (estimated) No. of Female Employees: 611582 (estimated)
Safety Information
| Hazard Codes | Xi:Irritant; |
|---|---|
| Risk Phrases | R36/38 |
| Safety Phrases | S26-S36/37-S37/39 |
| WGK Germany | 2 |
| RTECS | AH5075000 |
| HS Code | 2922499990 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
Synonyms
| Ethylenediaminetetraacetic acid tetrasodium salt |
| Tetrasodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate |
| Tetrasodium ethylenediaminetetraacetate |
| Tetrasodium salt EDTA |
| MFCD00012460 |
| EINECS 200-573-9 |
| Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt |
| Complexone |
| TETRASODIUM EDTA |
| Nullapon |
| N,N'-Ethylenediaminediacetic acid tetrasodium salt |
| TETRACEMATE TETRASODIUM |
| Tetrasodium salt of EDTA |
| EDTA tetrasodium salt |
| Tetrasodium edetate |
| Nervanaid B |
| EDETIC ACID TETRASODIUM SALT |
| EDTA sodium |
| Tetrasodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate |
| Edetate Sodium |
| EDTA Tetrasodium |
| Endrate tetrasodium |
| Sodium edetate |
| EDTA-4NA |
