CAS 774596-22-4|Cetirizine D8

Introduction：Basic information about CAS 774596-22-4|Cetirizine D8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cetirizine D8 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Cetirizine D8
CAS Number	774596-22-4	Molecular Weight	469.85900
Density	/	Boiling Point	/
Molecular Formula	C₂₁H₁₇D₈ClN₂O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Cetirizine-D8
Synonym	More Synonyms

Cetirizine D8 BiologicalActivity

Description	Cetirizine D8 is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor
Target	H1 receptor
References	[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993. [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Chemical & Physical Properties

Molecular Formula	C₂₁H₁₇D₈ClN₂O₃
Molecular Weight	469.85900
Exact Mass	468.15900
PSA	53.01000
LogP	4.62800
InChIKey	ZKLPARSLTMPFCP-BGKXKQMNSA-N
SMILES	O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1

Synonyms

[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethoxy]acetic acid

Acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethoxy]-

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