Introduction：Basic information about CAS 23288-49-5|Probucol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Probucol |
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| CAS Number | 23288-49-5 | Molecular Weight | 516.842 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 546.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C31H48O2S2 | Melting Point | 117 118ºC |
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| MSDS | ChineseUSA | Flash Point | 264.9±28.8 °C |
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Names
| Name | probucol |
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| Synonym | More Synonyms |
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Probucol BiologicalActivity
| Description | Probucol is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.Target: OthersProbucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. Probucol inhibited cholesterol efflux up to 80% in J774 macrophages expressing ABCA1. probucol is an effective inhibitor of ABCA1-mediated cholesterol efflux without influencing scavenger receptor class B type I-mediated efflux. The inhibition of ABCA1 translocation to the plasma membrane may in part explain the reported in vivo high-density lipoprotein-lowering action of probucol [1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic DiseaseNatural Products >>Phenols |
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| References | [1]. Probucol |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 546.7±50.0 °C at 760 mmHg |
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| Melting Point | 117 118ºC |
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| Molecular Formula | C31H48O2S2 |
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| Molecular Weight | 516.842 |
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| Flash Point | 264.9±28.8 °C |
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| Exact Mass | 516.309570 |
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| PSA | 91.06000 |
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| LogP | 10.27 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.574 |
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| InChIKey | FYPMFJGVHOHGLL-UHFFFAOYSA-N |
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| SMILES | CC(C)(Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)Sc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1 |
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| Storage condition | Desiccate at +4°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AL3705000
- CHEMICAL NAME :
- Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole
- CAS REGISTRY NUMBER :
- 23288-49-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C31-H48-O2-S2
- MOLECULAR WEIGHT :
- 516.91
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 3650 mg/kg/1Y-I
- TOXIC EFFECTS :
- Behavioral - general anesthetic Cardiac - cardiomegaly Cardiac - pulse rate increase, without fall in BP
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 326,1435,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 40,833,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1042,1990
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S23-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | AL3705000 |
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| HS Code | 29093090 |
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Customs
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol] |
| Biphenabid |
| Phenol, 4,4'-[(1-methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)- |
| Lursell |
| EINECS 245-560-9 |
| Probucol |
| 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol |
| Acetone Bis(3,5-di-tert-butyl-4-hydroxyphenyl)mercaptole |
| Bisbid |
| [14C]-Probucol |
| Panavir |
| Sinlestal |
| Lurselle |
| 4,4'-((1-methylethylidene)-bis(thio))-bis(2,6-bis(1,1-dimethylethyl)phenol) |
| 4,4'-[(1-methylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] |
| 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol) |
| 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol] |
| Probucolum |
| MFCD00079281 |
| Lesterol |
| Lorelco |
| Bisphenabid |
| 4,4'-(isopropylidenedithio)-bis-(2,6-di-tert-butylphenol) |
| 4,4'-(2,2-Propanediyldisulfanediyl)bis[2,6-bis(2-methyl-2-propanyl)phenol] |
