Introduction：Basic information about CAS 1852-38-6|Pregnenolone sulfate sodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pregnenolone sulfate sodium salt |
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| CAS Number | 1852-38-6 | Molecular Weight | 418.52300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H31NaO5S | Melting Point | 192ºC(lit.) |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | sodium,(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) sulfate |
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| Synonym | More Synonyms |
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Pregnenolone sulfate sodium salt BiologicalActivity
| Description | Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication[1][2]. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Cannabinoid Receptor |
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| Target | CB1 Human Endogenous Metabolite |
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| In Vitro | CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy[1]. The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1]. |
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| In Vivo | Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. |
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| Animal Admin | Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1]. |
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| References | [1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [2]. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. |
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Chemical & Physical Properties
| Melting Point | 192ºC(lit.) |
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| Molecular Formula | C21H31NaO5S |
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| Molecular Weight | 418.52300 |
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| Exact Mass | 418.17900 |
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| PSA | 91.88000 |
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| LogP | 5.08060 |
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| InChIKey | QQVJEIZJHDPTSH-UHFFFAOYSA-M |
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| SMILES | CC(=O)C1CCC2C3CC=C4CC(OS(=O)(=O)[O-])CCC4(C)C3CCC12C.[Na+] |
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Safety Information
Synonyms
| Pregnenolone sulfate sodium salt |
| Pregnenolone-3-sulfate sodium salt |
