CAS 69563-88-8|GI-530159

Introduction：Basic information about CAS 69563-88-8|GI-530159, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. GI-530159 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	GI-530159
CAS Number	69563-88-8	Molecular Weight	518.450
Density	1.4±0.1 g/cm3	Boiling Point	544.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₀F₆N₂O₂	Melting Point	159-163 °C(lit.)
MSDS	ChineseUSA	Flash Point	283.3±30.1 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane
Synonym	More Synonyms

GI-530159 BiologicalActivity

Description	GI-530159 is a selective, mechanosensitive opener of TREK1 (K2P2.1) and TREK2 (K2P10.1) channels, with an EC50 of 0.76 μM for TREK1. GI-530159 displays selectivity for TREK1/2 over TRAAK, TASK3 and other potassium channels. GI-530159 reduces rat dorsal root ganglion neuron excitability[1].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
References	[1]. Loucif AJC, et al. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018;175(12):2272-2283.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	544.8±50.0 °C at 760 mmHg
Melting Point	159-163 °C(lit.)
Molecular Formula	C₂₇H₂₀F₆N₂O₂
Molecular Weight	518.450
Flash Point	283.3±30.1 °C
Exact Mass	518.142883
PSA	70.50000
LogP	4.57
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.579
InChIKey	HHLMWQDRYZAENA-UHFFFAOYSA-N
SMILES	Nc1ccc(Oc2ccc(C(c3ccc(Oc4ccc(N)cc4)cc3)(C(F)(F)F)C(F)(F)F)cc2)cc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1213000

CHEMICAL NAME :: Benzenamine, 4,4'-((2,2,2-trifluoro-1-(trifluoromethyl)ethylidene) bis(4,1-phenyleneoxy) )bis-

CAS REGISTRY NUMBER :: 69563-88-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1340 mg/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg/28D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0529936-1

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CY1213000
HS Code	2922299090

Customs

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

2,2-bis(4-[4-aminophenoxy]phenyl)hexafluoropropane

2,2-bis[4-(p-aminophenoxy)phenyl]hexafluoropropane

4,4'-[(1,1,1,3,3,3-Hexafluoro-2,2-propanediyl)bis(4,1-phenyleneoxy)]dianiline

2,2-bis[4-(4'-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropane

Benzenamine, 4,4'-[[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis-

2,2-bis[4-(4-aminophenoxy)-phenyl]hexafluoropropane

4,4'-[(1,1,1,3,3,3-hexafluoropropane-2,2-diyl)bis(benzene-4,1-diyloxy)]dianiline

HFBAPP

MFCD00015723

[1,1-bis(trifluoromethyl)-1,1-bis(4-(4-amino-phenoxy)-phenyl)]methane

1,1,1,3,3,3-hexafluoro-2,2-bis[4-(4-aminophenoxy)phenyl]propane

isbenzenamine

2,2'-BIS[4-(4-AMINOPHENOXY)PHENY]HEXAFLUOROPROPANE

BAPOFP

BIS-AF-A

4-BDAF

leneoxy))bis

4',4'''-(Hexafluoroisopropylidene)-bis-(4-phenoxyaniline)

4,4'-[(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)bis(4,1-phenyleneoxy)]dianiline

2,2-BIS[4-(4-AMINOPH

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