Introduction：Basic information about CAS 92562-88-4|Lagociclovir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lagociclovir |
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| CAS Number | 92562-88-4 | Molecular Weight | 269.232 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | 633.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C10H12FN5O3 | Melting Point | / |
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| MSDS | / | Flash Point | 336.9±34.3 °C |
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Names
| Name | 2-amino-9-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one |
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| Synonym | More Synonyms |
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Lagociclovir BiologicalActivity
| Description | Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HBVResearch Areas >>Infection |
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| References | [1]. Michalak TI, et al. Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B. Antimicrob Agents Chemother. 2009 Sep;53(9):3803-14. |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Boiling Point | 633.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C10H12FN5O3 |
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| Molecular Weight | 269.232 |
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| Flash Point | 336.9±34.3 °C |
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| Exact Mass | 269.092407 |
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| PSA | 119.05000 |
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| LogP | -0.53 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.834 |
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Synonyms
| Guanosine, 2',3'-dideoxy-3'-fluoro- |
| UNII-UU109JJU0U |
| Guanosine,2',3'-dideoxy-3'-fluoro |
| Fddguo |
| 3'-fluoro-2',3'-dideoxyguanosine |
| 2',3'-Dideoxy-3'-fluoroguanosine |
| Lagociclovir |
| 3'-fluoro-3'-deoxyguanosine |
| 3'-FddG |
