CAS 34552-84-6|Isoxicam
| Common Name | Isoxicam | ||
|---|---|---|---|
| CAS Number | 34552-84-6 | Molecular Weight | 335.335 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 518.8ºC at 760mmHg |
| Molecular Formula | C14H13N3O5S | Melting Point | 265-271℃ |
| MSDS | ChineseUSA | Flash Point | 267.5ºC |
Names
| Name | isoxicam |
|---|---|
| Synonym | More Synonyms |
Isoxicam BiologicalActivity
| Description | Isoxicam is an orally active, long-acting, non-steroidal anti-inflammatory agent for the research of arthritis[1]. Isoxicam is a nonselective inhibitor of COX-1 and COX-2[2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| Target | COX-1 COX-2 |
| References | [1]. DiPasquale G, et al. The antiinflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide). Agents Actions. 1975 Aug;5(3):256-63. [2]. Xu S, et al. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289(10):6799-808. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 518.8ºC at 760mmHg |
| Melting Point | 265-271℃ |
| Molecular Formula | C14H13N3O5S |
| Molecular Weight | 335.335 |
| Flash Point | 267.5ºC |
| Exact Mass | 335.057587 |
| PSA | 121.12000 |
| LogP | 1.38 |
| Index of Refraction | 1.686 |
| InChIKey | YYUAYBYLJSNDCX-UHFFFAOYSA-N |
| SMILES | Cc1cc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)no1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 7,481,1977
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | DL0703000 |
Articles26
More Articles| Effect of some new prostaglandin synthetase inhibitors on the endotoxin induced mortality and biochemical changes in experimental animals. Res. Commun. Chem. Pathol. Pharmacol. 60(1) , 19-25, (1988) The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All ... | |
| [The effect of estro-progesterones on the inflammatory episodes of hand arthroses. Apropos of a case]. Rev. Rhum. Mal. Osteoartic. 56(10) , 709-11, (1989) | |
| Controlled-release naproxen compared with isoxicam in patients with osteoarthritis. Curr. Med. Res. Opin. 11(1) , 28-33, (1988) The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications w... |
Synonyms
| 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-, 1,1-dioxide |
| Isoxicam |
| Isoxicamo [INN-Spanish] |
| 4-Hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
| 4-hydroxy-2-methyl-N-(5-methylisoxazol-3-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
| Isoxicamo |
| 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
| N-(5-methyl-3-isoxazolyl)-4-hydroxy-2-methyl-2H-1,2-benzthiazine-3-carboxamide 1,1-dioxide |
| EINECS 252-084-5 |
| 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-1λ<sup>6</sup>,2-benzothiazine-3-carboxamide |
| Isoxicamum [INN-Latin] |
| Maxicam |
| UNII:8XU734C4NG |
| Pacyl (antiinflammatory) |
| Isoxicamum |
| UNII-8XU734C4NG |
| 4-Hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide |
