CAS 63-56-9|thonzylamine hydrochloride

Introduction：Basic information about CAS 63-56-9|thonzylamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Synonyms

Common Name	thonzylamine hydrochloride
CAS Number	63-56-9	Molecular Weight	322.833
Density	1.2562 (rough estimate)	Boiling Point	bp2.2 185-187°
Molecular Formula	C₁₆H₂₃ClN₄O	Melting Point	173 - 176ºC
MSDS	/	Flash Point	220.3ºC

Names

Name	N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine,hydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.2562 (rough estimate)
Boiling Point	bp2.2 185-187°
Melting Point	173 - 176ºC
Molecular Formula	C₁₆H₂₃ClN₄O
Molecular Weight	322.833
Flash Point	220.3ºC
Exact Mass	322.156036
PSA	41.49000
LogP	2.85540
Index of Refraction	1.5800 (estimate)
InChIKey	HRYJPHOTGFERGT-UHFFFAOYSA-N
SMILES	COc1ccc(CN(CCN(C)C)c2ncccn2)cc1.Cl
Stability	Stable. Incompatible with strong oxidizing agents.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8750000

CHEMICAL NAME :: Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride

CAS REGISTRY NUMBER :: 63-56-9

LAST UPDATED :: 198812

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H22-N4-O.Cl-H

MOLECULAR WEIGHT :: 322.88

WISWESSER LINE NOTATION :: T6N CNJ BN1R DO1&2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,419,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 157 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,83S,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 493 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 38200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974

Safety Information

Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36

Synonyms

Novohetramin

Thonzylaminium chloride

N,N-Dimethyl-N'-(p-methoxybenzyl)-N'-(2-pyrimidyl)ethylenediamine Hydrochloride

Anahist

N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyrimidinyl-1,2-ethanediamineMonohydrochloride

EINECS 200-561-3

Thonzylamine HCl

1,2-Ethanediamine, N-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N-2-pyrimidinyl-, hydrochloride (1:1)

UNII-6K9YKD48Y4

THONZYLAMINE HYDROCHLORIDE

N-(4-Methoxybenzyl)-N',N'-dimethyl-N-(2-pyrimidinyl)-1,2-ethanediamine hydrochloride (1:1)

N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine hydrochloride

N-(4-methoxybenzyl)-N',N'-dimethyl-N-(pyrimidin-2-yl)ethane-1,2-diamine hydrochloride (1:1)

Resistab

Neohetramine hydrochloride

2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride

Recommended......