CAS 34787-01-4|Ticarcillin
| Common Name | Ticarcillin | ||
|---|---|---|---|
| CAS Number | 34787-01-4 | Molecular Weight | 384.427 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 768.3±60.0 °C at 760 mmHg |
| Molecular Formula | C15H16N2O6S2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 418.4±32.9 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | ticarcillin |
|---|---|
| Synonym | More Synonyms |
Ticarcillin BiologicalActivity
| Description | Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1]. Cell Viability Assay[2] Cell Line: Ps. aeruginosa Concentration: 10 mg/L Incubation Time: 18 hours Result: Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L. |
| In Vivo | Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect[2]. Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2]. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Increased effect significantly (0.001 < P < 0.0025) with increasing dose. Animal Model: Swiss type male mice injected with Ps. aeruginosa[2] Dosage: 50, 100, 200 mg/kg Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once Result: Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min) Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26 100 26.14 (0.60) 1.53 (0.11) 27 200 54.56 (2.90) 1.47 (0.12) 28 |
| References | [1]. Cecile Formosa, et al. Nanoscale effects of antibiotics on P. aeruginosa. Nanomedicine. 2012 Jan;8(1):12-6. [2]. G B van der Voet, et al. Comparison of the antibacterial activity of azlocillin and ticarcillin in vitro and in irradiated neutropenic mice. J Antimicrob Chemother. 1985 Nov;16(5):605-13. [3]. Oriel Spierer, et al. Comparative activity of antimicrobials against Pseudomonas aeruginosa, Achromobacter xylosoxidans and Stenotrophomonas maltophilia keratitis isolates. Br J Ophthalmol. 2018 May;102(5):708-712. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 768.3±60.0 °C at 760 mmHg |
| Molecular Formula | C15H16N2O6S2 |
| Molecular Weight | 384.427 |
| Flash Point | 418.4±32.9 °C |
| Exact Mass | 384.044983 |
| PSA | 177.55000 |
| LogP | 0.69 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.694 |
| InChIKey | OHKOGUYZJXTSFX-KZFFXBSXSA-N |
| SMILES | CC1(C)SC2C(NC(=O)C(C(=O)O)c3ccsc3)C(=O)N2C1C(=O)O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R42/43 |
| Safety Phrases | 22-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Synonyms
| (2S,5R,6R)-6-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Temocillin Disodium |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[(carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-,[2S-[2a,5a,6b(S*)]] |
| 6-[D(-)-a-Carboxy-3-thienylacetamido]penicillanic Acid |
| EINECS 252-213-5 |
| (2S,5R,6R)-6-{[(2R)-2-Carboxy-2-(3-thienyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Ticarcillin |
| (2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-yl-acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| 6-[D-(-)-a-Carboxy-3-thienylacetamido]penicillanic acid |
| a-Carboxy-3-thienylmethylpenicillin |
| N-(2-Carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-3-thiophenemalonamic Acid |
| 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- |
| TRIARCILLIN |
| MFCD00864998 |
| Ticcarcillin acid |
