CAS 491-54-3|Kaempferide

Introduction：Basic information about CAS 491-54-3|Kaempferide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Kaempferide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles4
7. Synonyms

Common Name	Kaempferide
CAS Number	491-54-3	Molecular Weight	300.263
Density	1.5±0.1 g/cm3	Boiling Point	543.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₂O₆	Melting Point	156-157ºC(lit.)
MSDS	USA	Flash Point	207.1±23.6 °C

Names

Name	kaempferide
Synonym	More Synonyms

Kaempferide BiologicalActivity

Description	Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Others >>Estrogen Receptor/ERRNatural Products >>FlavonoidsResearch Areas >>Others
References	[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5. [2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8. [3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16. [4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

Description

Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Others >>Estrogen Receptor/ERRNatural Products >>FlavonoidsResearch Areas >>Others

References

[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5.

[2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8.

[3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16.

[4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	543.8±50.0 °C at 760 mmHg
Melting Point	156-157ºC(lit.)
Molecular Formula	C₁₆H₁₂O₆
Molecular Weight	300.263
Flash Point	207.1±23.6 °C
Exact Mass	300.063385
PSA	100.13000
LogP	2.74
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.710
InChIKey	SQFSKOYWJBQGKQ-UHFFFAOYSA-N
SMILES	COc1ccc(-c2oc3cc(O)cc(O)c3c(=O)c2O)cc1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6915000

CHEMICAL NAME :: Flavanone, 4'-methoxy-3,5,7-trihydroxy-

CAS REGISTRY NUMBER :: 491-54-3

BEILSTEIN REFERENCE NO. :: 0305378

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O6

MOLECULAR WEIGHT :: 300.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	KD4170000
HS Code	29329990

Articles4

Metabolite profiling of polyphenols in the Tunisian plant Tamarix aphylla (L.) Karst.

J. Pharm. Biomed. Anal. 99 , 97-105, (2014)

In this study, a detailed investigation on the composition of polyphenols of Tamarix aphylla (L.) Karst., consisting of phenolic acids and flavonoids, was carried out. In order to optimize the yield o...

Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) with selected reaction monitoring.

J. Pharm. Biomed. Anal. 97 , 166-77, (2014)

Alpinia oxyphylla (Yizhi) capsularfruits are commonly used in traditional medicine. Pharmacological studies have demonstrated that A. oxyphylla capsularfruits have some beneficial roles. Besides volat...

Highly sensitive analysis of flavonoids by zwitterionic microemulsion electrokinetic chromatography coupled with light-emitting diode-induced fluorescence detection.

J. Chromatogr. A. 1358 , 277-84, (2014)

A rapid zwitterionic microemulsion electrokinetic chromatography (ZI-MEEKC) approach coupled with light-emitting-diode-induced fluorescence (LED-IF, 480nm) detection was proposed for the analysis of f...

Synonyms

4'-O-Methylkaempferol

Kaempferol 4'-methyl ether

3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

3,5,7-trihydroxy-4'-methoxyflavone

Kaempferid

Kaempferide

3 5 7-trihydroxy-4'-methoxyflavone

4'-Methoxy-3,5,7-trihydroxyflavone

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-

3,5,7-trihydroxy-4′-methoxyflavone

4'-Methylkaempferol

Recommended......