Introduction：Basic information about CAS 97628-92-7|1-benzyloxycarbonylazetidine-3-carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-benzyloxycarbonylazetidine-3-carboxylic acid |
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| CAS Number | 97628-92-7 | Molecular Weight | 235.236 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 421.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C12H13NO4 | Melting Point | / |
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| MSDS | / | Flash Point | 208.5±28.7 °C |
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Names
| Name | 1-Cbz-Azetidine-3-carboxylic acid |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 421.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C12H13NO4 |
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| Molecular Weight | 235.236 |
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| Flash Point | 208.5±28.7 °C |
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| Exact Mass | 235.084457 |
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| PSA | 66.84000 |
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| LogP | 0.88 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.599 |
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| InChIKey | PVJPBKZGIUAESY-UHFFFAOYSA-N |
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| SMILES | O=C(O)C1CN(C(=O)OCc2ccccc2)C1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-[(Benzyloxy)carbonyl]-3-azetidinecarboxylic acid |
| 1,3-Azetidinedicarboxylic acid, 1-(phenylmethyl) ester |
| 1-phenylmethoxycarbonylazetidine-3-carboxylic acid |
