CAS 646-06-0|1,3-Dioxolane
Introduction：Basic information about CAS 646-06-0|1,3-Dioxolane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,3-Dioxolane | ||
|---|---|---|---|
| CAS Number | 646-06-0 | Molecular Weight | 74.078 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 75.6±0.0 °C at 760 mmHg |
| Molecular Formula | C3H6O2 | Melting Point | −95 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 1.7±0.0 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | 1,3-dioxolane |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 75.6±0.0 °C at 760 mmHg |
| Melting Point | −95 °C(lit.) |
| Molecular Formula | C3H6O2 |
| Molecular Weight | 74.078 |
| Flash Point | 1.7±0.0 °C |
| Exact Mass | 74.036781 |
| PSA | 18.46000 |
| LogP | -0.73 |
| Vapour density | 2.6 (vs air) |
| Vapour Pressure | 114.6±0.1 mmHg at 25°C |
| Index of Refraction | 1.397 |
| InChIKey | WNXJIVFYUVYPPR-UHFFFAOYSA-N |
| SMILES | C1COCO1 |
| Stability | Below 4°C |
| Water Solubility | SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20650 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - renal function tests depressed
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10500 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 32000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 8480 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1360 mg/m3/4H/22W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3000 ppm/6H/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1360 mg/m3/4H/22W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - other changes
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105000 mg/m3/50D-I
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 290 mg/kg
- REFERENCE :
- STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 107,205,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 50 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84001 No. of Facilities: 256 (estimated) No. of Industries: 13 No. of Occupations: 23 No. of Employees: 10612 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84001 No. of Facilities: 5264 (estimated) No. of Industries: 86 No. of Occupations: 44 No. of Employees: 74949 (estimated) No. of Female Employees: 747 (estimated)
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 290 mg/kg
- REFERENCE :
- STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 107,205,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 10 mg/m3;STEL 20 mg/m3;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 50 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84001 No. of Facilities: 256 (estimated) No. of Industries: 13 No. of Occupations: 23 No. of Employees: 10612 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84001 No. of Facilities: 5264 (estimated) No. of Industries: 86 No. of Occupations: 44 No. of Employees: 74949 (estimated) No. of Female Employees: 747 (estimated)
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H319 |
| Precautionary Statements | P210-P305 + P351 + P338-P370 + P378-P403 + P235 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US) |
| Hazard Codes | F:Flammable; |
| Risk Phrases | R11 |
| Safety Phrases | S16 |
| RIDADR | UN 1166 3/PG 2 |
| WGK Germany | 1 |
| RTECS | JH6760000 |
| Packaging Group | II |
| Hazard Class | 3 |
| HS Code | 29329970 |
Customs
| HS Code | 29329970 |
|---|
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Synonyms
| 1.3-dioxolane |
| 1,4-dioxolane |
| 1,3-Dioxolan |
| 1,3-dioxalane |
| Formal glycol |
| MFCD00003207 |
| ethylene glycol methylene ether |
| trans dioxolane |
| ethylene glycol formal |
| EINECS 211-463-5 |
| cis dioxolane |
| dioxolane, 1,3- |
| 1,3-dioxacyclopentane |
| Glycol formal |
| 1,3-Dioxolane |
