CAS 175553-48-7|(2S)-(+)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE
Introduction：Basic information about CAS 175553-48-7|(2S)-(+)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2S)-(+)-1-BENZOYL-2-TERT-BUTYL-3-METHYL-4-IMIDAZOLIDINONE | ||
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| CAS Number | 175553-48-7 | Molecular Weight | 393.43400 |
| Density | / | Boiling Point | 741.2ºC at 760mmHg |
| Molecular Formula | C19H27N3O6 | Melting Point | / |
| MSDS | / | Flash Point | 402.1ºC |
Names
| Name | 1-(6-amino-5-oxooctan-4-yl)-2,3-dihydroindole-2-carboxamide,oxalate |
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BiologicalActivity
| Description | Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| Target | IC50: 7 nM (TPP II) and 10 μM (TPP I)[1] |
| In Vitro | Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2]. |
| In Vivo | Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2]. Animal Model: Mice (25-30 g) Dosage: 10 mg/kg Administration: Intravenous injection; for 20 minutes Result: Reduces food intake and elicits other behavioral concomitants of satiation. |
| References | [1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. |
Chemical & Physical Properties
| Boiling Point | 741.2ºC at 760mmHg |
|---|---|
| Molecular Formula | C19H27N3O6 |
| Molecular Weight | 393.43400 |
| Flash Point | 402.1ºC |
| Exact Mass | 393.19000 |
| PSA | 150.03000 |
| LogP | 1.90970 |
| Vapour Pressure | 4.53E-23mmHg at 25°C |
| InChIKey | HAQIRIMIVLFYIX-ZFWWWQNUSA-N |
| SMILES | CCCCNC(=O)C1Cc2ccccc2N1C(=O)C(N)CC |
