CAS 92169-45-4|Neuromedin N trifluoroacetate salt

Introduction：Basic information about CAS 92169-45-4|Neuromedin N trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Neuromedin N trifluoroacetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Neuromedin N trifluoroacetate salt
CAS Number	92169-45-4	Molecular Weight	745.94900
Density	/	Boiling Point	/
Molecular Formula	C₃₈H₆₃N₇O₈	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	2-[[2-[[2-[[1-[2-(2,6-diaminohexanoylamino)-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Synonym	More Synonyms

Neuromedin N trifluoroacetate salt BiologicalActivity

Description	Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Sequence: Lys-Ile-Pro-Tyr-Ile-Leu.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological DiseasePeptides
Target	Dopamine D2 receptor[1].
In Vitro	Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].
References	[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.

Chemical & Physical Properties

Molecular Formula	C₃₈H₆₃N₇O₈
Molecular Weight	745.94900
Exact Mass	745.47400
PSA	246.28000
LogP	4.44620
InChIKey	RZMLVIHXZGQADB-UHFFFAOYSA-N
SMILES	CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCN1C(=O)C(NC(=O)C(N)CCCCN)C(C)CC)C(=O)NC(CC(C)C)C(=O)O
Storage condition	-20°C

Synonyms

neuromedin N

Lys-ile-pro-tyr-ile-leu

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