Introduction：Basic information about CAS 78538-74-6|FG 7142, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FG 7142 |
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| CAS Number | 78538-74-6 | Molecular Weight | 225.24600 |
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| Density | 1.328g/cm3 | Boiling Point | 576.3ºC at 760 mmHg |
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| Molecular Formula | C13H11N3O | Melting Point | / |
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| MSDS | USA | Flash Point | 302.3ºC |
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Names
| Name | N-Methyl-b-carboline-3-carboxamide |
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| Synonym | More Synonyms |
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FG 7142 BiologicalActivity
| Description | FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| In Vitro | FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively[1]. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits (EC50: α2= 507 nM,α3=1.021μM , α5=1.439 μM)[1]. |
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| In Vivo | FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats[1]. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas[1]. |
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| References | [1]. Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32(5):1069-81. Epub 2006 Nov 1. |
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Chemical & Physical Properties
| Density | 1.328g/cm3 |
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| Boiling Point | 576.3ºC at 760 mmHg |
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| Molecular Formula | C13H11N3O |
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| Molecular Weight | 225.24600 |
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| Flash Point | 302.3ºC |
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| Exact Mass | 225.09000 |
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| PSA | 57.78000 |
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| LogP | 2.46660 |
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| Index of Refraction | 1.735 |
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| InChIKey | QMCOPDWHWYSJSA-UHFFFAOYSA-N |
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| SMILES | CNC(=O)c1cc2c(cn1)[nH]c1ccccc12 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UU9780100
- CHEMICAL NAME :
- 9H-Pyrido(3,4-b)indole-3-carboxamide, N-methyl-
- CAS REGISTRY NUMBER :
- 78538-74-6
- LAST UPDATED :
- 199212
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C13-H11-N3-O
- MOLECULAR WEIGHT :
- 225.27
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- female 12-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 22,53,1991
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | UU9780100 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| B-carboline-3-carboxylic acid N-*methylamide |
| FG 7142 |
