CAS 90494-79-4|Xaliproden hydrochloride
| Common Name | Xaliproden hydrochloride | ||
|---|---|---|---|
| CAS Number | 90494-79-4 | Molecular Weight | 417.89400 |
| Density | / | Boiling Point | 487.8ºC at 760mmHg |
| Molecular Formula | C24H23ClF3N | Melting Point | / |
| MSDS | USA | Flash Point | 248.8ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine,hydrochloride |
|---|---|
| Synonym | More Synonyms |
Xaliproden hydrochloride BiologicalActivity
| Description | Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | 5-HT1A Receptor:3 nM (IC50) D2 Receptor:0.1-1 μM (IC50) |
| References | [1]. Cervo L, et, al. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. Eur J Pharmacol. 1994 Feb 21; 253(1-2): 139-47. [2]. Simiand J, et, al. Neuropsychopharmacological profile in rodents of SR 57746A, a new, potent 5-HT1A receptor agonist. Fundam Clin Pharmacol. 1993;7(8):413-27. [3]. Fournier J, et, al. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience. 1993 Aug; 55(3): 629-41. |
Chemical & Physical Properties
| Boiling Point | 487.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C24H23ClF3N |
| Molecular Weight | 417.89400 |
| Flash Point | 248.8ºC |
| Exact Mass | 417.14700 |
| PSA | 3.24000 |
| LogP | 6.93030 |
| InChIKey | WVHBEIJGAINUBW-UHFFFAOYSA-N |
| SMILES | Cl.FC(F)(F)c1cccc(C2=CCN(CCc3ccc4ccccc4c3)CC2)c1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| RTECS | UT8405666 |
Articles26
More Articles| 5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception. Br. J. Pharmacol. 158(1) , 232-42, (2009) Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro tran... | |
| Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats. Invest. Radiol. 37(6) , 321-7, (2002) The neurotrophic effect of Xaliproden has been followed using sequential cerebral magnetic resonance imaging (MRI) in rats with vincristine-induced brain lesion as a model of Alzheimer disease.Ninetee... | |
| The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: implications for multiple sclerosis treatment. Proc. Natl. Acad. Sci. U. S. A. 96(22) , 12855-9, (1999) Experimental autoimmune encephalomyelitis (EAE) is a T cell autoimmune disorder that is a widely used animal model for multiple sclerosis (MS) and, as in MS, clinical signs of EAE are associated with ... |
Synonyms
| Xaliproden hydrochloride |
