Introduction：Basic information about CAS 745046-84-8|Ivachtin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ivachtin |
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| CAS Number | 745046-84-8 | Molecular Weight | 447.462 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 665.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C20H21N3O7S | Melting Point | / |
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| MSDS | / | Flash Point | 356.0±34.3 °C |
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Names
| Name | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
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| Synonym | More Synonyms |
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Ivachtin BiologicalActivity
| Description | Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Neurological Disease |
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| Target | Caspase-3:23 nM (IC50) |
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| In Vitro | Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells[1]. |
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| References | [1]. Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 665.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C20H21N3O7S |
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| Molecular Weight | 447.462 |
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| Flash Point | 356.0±34.3 °C |
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| Exact Mass | 447.110016 |
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| PSA | 131.56000 |
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| LogP | 1.30 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.632 |
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| InChIKey | MWXJJTMEUGWKKY-UHFFFAOYSA-N |
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| SMILES | CC(=O)OCCN1C(=O)c2c(C)nc3ccc(S(=O)(=O)N4CCOCC4)cc3c2C1=O |
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Synonyms
| 2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate |
| 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)- |
| IVACHTIN |
| Caspase-3 Inhibitor VII |
| HMS3269H15 |
| 2-[4-Methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate |
